Around the world, researchers are working extremely hard to develop new treatments and interventions for COVID-19 with new clinical trials opening nearly every day. This directory provides you with information, including enrollment detail, about these trials. In some cases, researchers are able to offer expanded access (sometimes called compassionate use) to an investigational drug when a patient cannot participate in a clinical trial.
The information provided here is drawn from ClinicalTrials.gov. If you do not find a satisfactory expanded access program here, please search in our COVID Company Directory. Some companies consider expanded access requests for single patients, even if they do not show an active expanded access listing in this database. Please contact the company directly to explore the possibility of expanded access.
Emergency INDs
To learn how to apply for expanded access, please visit our Guides designed to walk healthcare providers, patients and/or caregivers through the process of applying for expanded access. Please note that given the situation with COVID-19 and the need to move as fast as possible, many physicians are requesting expanded access for emergency use. In these cases, FDA will authorize treatment by telephone and treatment can start immediately. For more details, consult FDA guidance. Emergency IND is the common route that patients are receiving convalescent plasma.
Search Tips
To search this directory, simply type a drug name, condition, company name, location, or other term of your choice into the search bar and click SEARCH. For broadest results, type the terms without quotation marks; to narrow your search to an exact match, put your terms in quotation marks (e.g., “acute respiratory distress syndrome” or “ARDS”). You may opt to further streamline your search by using the Status of the study and Intervention Type options. Simply click one or more of those boxes to refine your search.
Displaying 30 of 159VA Office of Research and Development
This is study is comprised of three approaches. First, the investigators will conduct aretrospective cohort study to determine factors associated with COVID-19 severity andcomplications and understand COVID-19 outcomes, including all-cause mortality,post-discharge events, and impacts of rehabilitation services (third aim). The second aimis a mixed-method study and follows COVID-19 patients with repeated surveys to determinepatient-reported functional outcomes, health recovery, and rehabilitation needs afterCOVID-19. The investigators will recruit patients and their informal caregivers forinterviews to assess their function and rehabilitation needs.
Augusta University
The purpose of this study is to test the effectiveness of prophylactic mouth rinses inreducing the amount of viruses, specifically SARS-CoV-2 in the oral cavity. This researchwill guide dental and medical providers on best practices to be performed prior to dentaland medical procedures involving the oral cavity.
Fondazione IRCCS Policlinico San Matteo di Pavia
The study assesses the efficacy of early administration of hyperimmune plasma in covid-19patients who are on CPAP or intubated. Efficacy is measured as a 2 point decrease in theWHO scale
Boston Children's Hospital
The purpose of this study is to advance the scientific understanding of how a prenatalCOVID-19 infection and associated psychological distress influences infantneurodevelopment. This project will aim to shed light on how families and childdevelopment are impacted by the current COVID-19 pandemic and will work to better supportthese families and children as they grow.
Karolinska University Hospital
Initially, it was suspected that Covid-19 would primarily affect the airways, but severalstudies have now shown that it is a disease with multisystem manifestations. Covid-19 hasthe potential to affect physical, cognitive, and psychological functions in multipleways. It has been clear that a significant proportion of patients with Covid-19 developlong-term symptoms. The term post-acute Covid-19 syndrome (PACS) is now used to describethe wide range of prolonged symptoms following the infection. Patients who have been inhospital for Covid-19 for a long time may need specialized rehabilitation, however, alsonon-hospitalized patients with mild symptoms may need specific rehabilitation to be ableto meet the complex symptoms and problems that may arise. Previous studies on therecovery and rehabilitation after other coronavirus shows the importance to developtailored interventions so that these patients receive appropriate rehabilitationThe aim of this study is to evaluate the effects of inspiratory muscle training on adultpatients with PACS and decreased respiratory muscle strength.A randomized controlled trial will be used. A total of 90 adult patients with PACS and 80% or less of predicted value in inspiratory muscle strength (maximal inspiratorypressure) will be eligible for enrollment. Patients will be randomized either to anintervention group or a control group. The intervention will consist of inspiratorymuscle training performed twice daily for 8 weeks. This will be combined with an 8-weekphysical exercise training program. The control group will perform the same physicalexercise training according to standard care. All measurements will be performed atbaseline and after 8 weeks.Primary outcome is maximal inspiratory pressure. Secondary outcomes are: Maximalexpiratory pressure, pulmonary function, physical capacity, physical activity,respiratory status and symptoms, health-related quality of life, work ability, fatigue,self-reported outcome measure of physical function and voice function.Covid-19 has the potential to affect physical, cognitive, and psychological functions inmultiple ways and lead to a negative impact on quality of life in the long-termperspective. Therefore, development of a rehabilitation program with specific tailoredinterventions will be necessary to improve physical and psychological function, as wellas health-related quality of life and work ability.
M.D. Anderson Cancer Center
This study investigates the changes in practice by pulmonary procedural programs acrossthe United States as they faced the coronavirus pandemic. Information gathered from thisstudy may help guide pulmonary programs on a wider scale and improve their practice. Thestudy may also help researchers understand where they should focus research efforts tobetter respond to a pandemic in the future.
Ministry of Health, Thailand
The purpose of this study is to examine the effect of Andrographis Extract, BoesenbergiaExtract compared to standard treatment in asymptomatic COVID patients.
Assistance Publique Hopitaux De Marseille
To measure the immunization rate (seroneutralization) in a population of exposed hospitalworkers (nursing staff assigned to dedicated COVID-19 care units, laboratory staffhandling COVID-19 samples).
Saglik Bilimleri Universitesi
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) caused a worldwide pandemicin over 100 years. The disease caused by this newly discovered virus was called Covid-19.In this study, we aimed to evaluate changing of PSA value in patients with Covid-19.
IRCCS Azienda Ospedaliero-Universitaria di Bologna
In recent months, more and more studies suggest tele-rehabilitation as a means to beexploited to reduce the risk of contagion.The intent of our study is to verify the effectiveness of a tele-rehabilitationintervention through the application of a respiratory rehabilitation program supported bycontact with physiotherapists, in patients with outcomes from SARS-CoV-2 infectiondischarged from the various medical departments and taken over by physiotherapists afterphysiatric evaluation.Faced with the same rehabilitation program prescribed to all patients, the primaryobjective of our study is to detect whether patients supported by remote rehabilitationafter hospitalization improve both adherence to the rehabilitation program andcardiorespiratory endurance and dyspnea symptoms assessed with the Six Minute WalkingTest scale (6MWT). This test is validated for multiple pathologies, including idiopathicpulmonary fibrosis, the clinic of which could be comparable to the outcomes ofcoronavirus interstitial pneumonia as suggested by the literature.The secondary objectives concern the assessment of the impact of physical exerciseassisted by tele-rehabilitation detected through: the assessment of the quality of life(Saint George Respiratory Questionnaire );the assessment of autonomy in daily lifeactivities (Barthel Index Dyspnea Scale), the evaluation of the variation in thoracicexpansion and lung volumes (with COACH , an instrument for respiratory physiotherapy thatmeasures the inspiratory volume in ml); the evaluation of muscle strength and endurance(One Minute Sit To Stand) ; the detection of dyspnea during the execution of theexercises (Modified Borg scale); the assessment of the functionality of the lower limbs(Short Physical Performance Battery)