The purpose of this study is to advance the scientific understanding of how a prenatal COVID-19 infection and associated psychological distress influences infant neurodevelopment. This project will aim to shed light on how families and child development are impacted by the current COVID-19 pandemic and will work to better support these families and children as they grow.
Prenatal exposure to maternal illness and stress has been widely associated with adverse
neurodevelopmental outcomes, including deficits in cognition and socioemotional development.
The principal goal of this project utilizes Magnetic Resonance Imaging (MRI),
Electroencephalography (EEG), and a variety of behavioral measures to assess brain maturation
and neurodevelopment among infants exposed prenatally to COVID-19 and associated high levels
of stress. The planned experiments are effective in identifying brain markers that may
contribute to resiliency in young infants, determining measures of stress response in
relation to a maternal COVID-19 diagnosis, and characterizing the neurodevelopment of those
infants born to mothers with a COVID-19 infection.
Specific goals include:
1. To determine the prevalence of psychological distress in pregnant women with a confirmed
COVID-19 diagnosis and to examine the extent to which existing high risk environments
play a role in the susceptibility of heightened psychological distress.
2. To examine the effects of prenatal distress and maternal illness/inflammation related to
a maternal COVID-19 diagnosis on early structural and functional brain development.
3. To characterize neural networks that may have been impacted by a maternal COVID-19
infection and related stress during pregnancy.
4. To assess the early neurodevelopment outcomes of infants exposed to elevated prenatal
stress related to a maternal COVID-19 diagnosis during pregnancy.
Other: No Intervention
No Intervention
Inclusion Criteria:
- English or Spanish- speaking of any ethnicity
- Women, aged 18 or older
- Women who received COVID-19 diagnoses during pregnancy OR Women without any SARS-CoV-2
positive test during pregnancy, any suspected COVID illness (even if not tested) or
who received a negative COVID-19 test result during pregnancy
Exclusion Criteria:
Participants will be excluded if the child:
- is born at less than 34 weeks or if birth weight is not appropriate for dates
- has an identified genetic, metabolic, syndromic or progressive neurological disorder
(e.g., Down Syndrome, Rett Syndrome, Tuberous Sclerosis, Neurofibromatosis, Fragile X
Syndrome) at birth or within the first year
Massachusetts General Hospital
Boston, Massachusetts, United States
Brigham and Women's Hospital
Boston, Massachusetts, United States
Laboratories of Cognitive Neuroscience, Boston Children's Hospital
Boston, Massachusetts, United States
Beth Israel Deaconess Medical Center
Boston, Massachusetts, United States
Charles Nelson, PhD
617 355-0400
familiesHEAL@childrens.harvard.edu
Erin Carmody
8572183011
familiesHEAL@childrens.harvard.edu
Charles A Nelson, PhD, Principal Investigator
Boston Children's Hospital