Around the world, researchers are working extremely hard to develop new treatments and interventions for COVID-19 with new clinical trials opening nearly every day. This directory provides you with information, including enrollment detail, about these trials. In some cases, researchers are able to offer expanded access (sometimes called compassionate use) to an investigational drug when a patient cannot participate in a clinical trial.
The information provided here is drawn from ClinicalTrials.gov. If you do not find a satisfactory expanded access program here, please search in our COVID Company Directory. Some companies consider expanded access requests for single patients, even if they do not show an active expanded access listing in this database. Please contact the company directly to explore the possibility of expanded access.
Emergency INDs
To learn how to apply for expanded access, please visit our Guides designed to walk healthcare providers, patients and/or caregivers through the process of applying for expanded access. Please note that given the situation with COVID-19 and the need to move as fast as possible, many physicians are requesting expanded access for emergency use. In these cases, FDA will authorize treatment by telephone and treatment can start immediately. For more details, consult FDA guidance. Emergency IND is the common route that patients are receiving convalescent plasma.
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Displaying 110 of 530Universitätsklinikum Köln
Coronavirus disease 2019 (COVID-19) which is caused by the virus Severe Acute RespiratorySyndrome Coronavirus-2 (SARS-CoV-2) has resulted in an ongoing global pandemic. It isunclear whether the relatively low number of reported cases of COVID-19 in people with CF(pwCF) is due to enhanced infection prevention practices or whether pwCF have protectivegenetic/immune factors. This study aims to prospectively assess the proportion of pwCF,including both adults and children with CF who have evidence of SARS-CoV-2 antibodiesover a two-year period. This study will also examine whether pwCF who have antibodies forSARS-CoV-2 have a different clinical presentation and what impact this has on their CFdisease. The proposed study will recruit pwCF from paediatric and adult CF centresthroughout the United Kingdom. Serological testing to detect antibodies will be performedon blood samples taken at month 0, 6, 12, 18 and 24 with additional time-points ifbloodwork is available via normal clinical care. Clinical data on, lung function,CF-related medical history, pulmonary exacerbations, antibiotic use, and microbiology andvaccination receipt, will be collected during routine clinical assessments.Associations will be examined between socio-demographic and clinical variables andserologic testing. The investigators will also examine the effects of SARS-CoV-2infection on clinical outcomes and analyse end-points to explore any age-related orgender-based differences, as well as subgroup analysis of outcomes in lung-transplantrecipients and pwCF receiving cystic fibrosis transmembrane conductance regulator (CFTR)modulator therapies. As pwCF receive COVID-19 vaccination the investigators will performa comparison of the development and progression of anti-SARS-CoV-2 antibodies in pwCFfollowing natural infection and vaccination SARS-CoV-2 over time.
Assistance Publique Hopitaux De Marseille
To measure the immunization rate (seroneutralization) in a population of exposed hospitalworkers (nursing staff assigned to dedicated COVID-19 care units, laboratory staffhandling COVID-19 samples).
King's College London
SATS is a single site feasibility study to assess the practical and psychologicalfeasibility of using rapid COVID antibody testing of blood obtained from fingertippin-pricks.
Semmelweis University Heart and Vascular Center
We aim to study if metabolic intensity and extent according to pathologic pulmonary18F-2-fluoro-2-deoxy-D-glucose (FDG)-uptake may correlate with the course of COVID-19pneumonia and potentially yield prognostic value. Moreover, we aim to assess permanentchanges after Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection,such as pulmonary fibrosis and neuropsychiatric symptoms (anosmia, depression, fatigue)where evaluation with FDG-positron emission tomography (PET/CT) might have an impact onfurther patient care.
National Natural Science Foundation of China
The study is designed to assess whether allergic rhinitis and allergen immunotherapyaffect the humoral response to SARS-CoV-2 Vaccination in adults. This is a prospectivestudy enrolling a total of approximately 120 subjects, 18-55 years old.
Liaquat University of Medical & Health Sciences
This study is aimed to investigate the treatment vitamin D3 as complementary therapy withroutine care for early mild symptoms of COVID-19 in outpatients setting.
Saglik Bilimleri Universitesi
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) caused a worldwide pandemicin over 100 years. The disease caused by this newly discovered virus was called Covid-19.In this study, we aimed to evaluate changing of PSA value in patients with Covid-19.
Mariam Ayman Amin Sharaf
Healthcare workers (HCWs) play a vital role in determining the success of vaccinationprograms. Patient acceptance and vaccination rely greatly on the utilization and attitudeof HCWs towards the vaccine, their attitude also influences patients' adherence tovaccination schedules and their hesitancy. HCWs themselves can be hesitant about acertain vaccine and thus can transfer their negative attitudes to their patients,increasing vaccine hesitancy among the general population. Frontline HCWs are at anincreased risk of exposure to COVID-19 due to their direct contact with their patients,working hours, psychological stress and job burnout, they also face stigma. Dental healthprofessionals in particular are at an increased risk due to their occupational hazardsthat include continuous exposure to body fluids and aerosols, this increases their riskof contracting COVID-19. Therefore vaccinating healthcare workers will be beneficial, notonly for themselves, but also for their households and patients.
IRCCS Azienda Ospedaliero-Universitaria di Bologna
In recent months, more and more studies suggest tele-rehabilitation as a means to beexploited to reduce the risk of contagion.The intent of our study is to verify the effectiveness of a tele-rehabilitationintervention through the application of a respiratory rehabilitation program supported bycontact with physiotherapists, in patients with outcomes from SARS-CoV-2 infectiondischarged from the various medical departments and taken over by physiotherapists afterphysiatric evaluation.Faced with the same rehabilitation program prescribed to all patients, the primaryobjective of our study is to detect whether patients supported by remote rehabilitationafter hospitalization improve both adherence to the rehabilitation program andcardiorespiratory endurance and dyspnea symptoms assessed with the Six Minute WalkingTest scale (6MWT). This test is validated for multiple pathologies, including idiopathicpulmonary fibrosis, the clinic of which could be comparable to the outcomes ofcoronavirus interstitial pneumonia as suggested by the literature.The secondary objectives concern the assessment of the impact of physical exerciseassisted by tele-rehabilitation detected through: the assessment of the quality of life(Saint George Respiratory Questionnaire );the assessment of autonomy in daily lifeactivities (Barthel Index Dyspnea Scale), the evaluation of the variation in thoracicexpansion and lung volumes (with COACH , an instrument for respiratory physiotherapy thatmeasures the inspiratory volume in ml); the evaluation of muscle strength and endurance(One Minute Sit To Stand) ; the detection of dyspnea during the execution of theexercises (Modified Borg scale); the assessment of the functionality of the lower limbs(Short Physical Performance Battery)
The Second Affiliated Hospital of Chongqing Medical University
On 11 February 2020, the International Committee for the Classification of Viruses namedthe disease caused by SAＲS-CoV-2 infection in humans as the new coronavirus pneumonia(coronavirus disease 2019, COVID-19). Due to the characteristics of livermicrocirculation disturbance and immune function disorder in patients with chronic liverdiseases (such as immune liver disease, chronic hepatitis C, liver cirrhosis, livercancer, etc.), those patients has a higher risk of infection than the general populationduring the epidemic period. More attention should be paid to personal protection anddisease prevention. Vaccination of COVID-19 vaccine can effectively prevent COVID-19virus infection and delay or prevent patients from developing into critical illness andreduce mortality. To evaluate the safety and effectiveness of COVID-19 vaccine in thosepatients with chronic liver diseases, and to guide the COVID-19 vaccination morescientifically, reasonably and effectively, this study was carried out.