This study will measure vitamin D levels in adults with COVID 19. Participants with low levels of vitamin D will be entered into an open label trial of supplementation with vitamin D.
Protocol for Part 1:
- A single blood draw at SCNM to measure levels of vitamin D and other nutrients,
comprehensive metabolic panel, and complete blood count with differential
- Completing a medical history/symptom form
- Completing a form about COVID-19 symptoms every 2 weeks for 6 weeks
- Authorization for release of medical records related to COVID 19 testing and/or
treatment.
Protocol for Part 2:
- Take a vitamin D supplement daily for two weeks, at a dosage of 10,000 IU/day b.i.d.
(age 18-69 years) or 15,000 IU/day t.i.d. (age 70+)
- After two weeks of taking vitamin D, return to SCNM for a blood draw to remeasure levels
of vitamin D, comprehensive metabolic panel, and complete blood count with differential.
If vitamin D levels are still below 30 ng/ml, continue the dosage for 3 more weeks. If
vitamin D levels are 30-49 ng/ml, continue at a dosage of 5000 IU/day. If vitamin D
levels are 50+ ng/ml, stop supplementation.
- Completing questionnaires about COVID 19 symptoms at 2, 4, and 6 weeks after treatment
begins (5 minutes each time).
Dietary Supplement: Vitamin D3
Oral vitamin D3 capsules
Inclusion Criteria for Part 1 (testing):
1. Adult age 18 or older
2. Previous positive test result for COVID 19
3. Able to communicate clearly in English Exclusion Criteria for Part 1 (testing): none
Inclusion Criteria for Part 2 (Vitamin D supplementation)
1. Participation in Part 1
2. Vitamin D level below 30 ng/ml
3. No abnormalities on the comprehensive metabolic panel that are clinically significant
to increasing the risk of an adverse reaction to vitamin D supplementation
Exclusion Criteria for Part 2 (Vitamin D supplementation):
1. Liver impairment
2. Clinical opinion of study physician that vitamin D supplementation could be harmful to
the participant.
3. Pregnancy
4. No symptoms for 2 weeks after positive COVID 19 test
5. Recovered from symptoms
Arizona State University
Tempe, Arizona, United States