The United Kingdom Multiple Sclerosis Register Covid-19 Substudy

Study objectives

1. To identify the incidence of upper respiratory tract symptoms: fever, cough and
breathing difficulties, other symptoms suggestive of COVID-19 infection, respiratory
tract infections suggestive of COVID-19, and COVID-19 confirmed by laboratory testing
among the UK MS population

2. To establish if some DMDs increase the risk of COVID-19 infection

3. To determine the incidence and effectiveness of self-isolation in the MS population. To
examine the impact self-isolation has on mood, fatigue, and other routinely collected
patient reported outcome measures from the MS Register.

4. To determine the clinical outcome of respiratory tract infections, including confirmed
and suspected cases of COVID-19, in terms of symptoms, time to recovery, hospital
admission, requirement for ventilation, and death.

5. To determine the longer-term impact of COVID-19 on MS, using routinely collected MS
outcomes in the MS register, including impact on disability, relapses and changes in
DMDs as assessed at 3 monthly intervals.

6. To determine where people are obtaining their health information during the COVID-19
outbreak.

7. To establish changes in DMDs prior to and as a result of symptoms related and unrelated
to COVID-19