It is clear now that SARS-CoV-2 could use angiotensin-converting enzyme 2 (ACE2), the same receptor as SARS-CoV Transmembrane protease serine type 2 (TMPRSS2), a protease belonging to the type II transmembrane serine protease family, cleaves the coronavirus spike protein Serine proteases are inhibited by a diverse group of inhibitors, The best-studied serpins are antithrombin and alpha 1-antitrypsin
Drug: alpha one antitrypsin inhalation
- we will give 8 ml of intravenous alpha one antitrypsin (alpha1-proteinase inhibitor (AATD)Glassia 50 ml) as nebulizer every 12 hours for 5 days
Inclusion Criteria:
1. Positive RT-PCR) assay for SARS-CoV-2
2. Age >18 years
3. Hospitalized
4. Able to give informed consent
Exclusion Criteria:
1. Known allergy to AAT
2. imminent death within next 24 hours
Ministry of Health
Mecca, Saudi Arabia
Investigator: mtair
Contact: 0555509022
research-makkah@moh.gov.sa
mohammed m othman
00966557881721
Ossman231@yahoo.com
mohammed m othman, Principal Investigator
MOH