Open label two arms, non randomized Convalescent Plasma treatment to severe and critical pneumonia COVID-19 hospitlaized patients compared to a historical cohort with matched controls.
We will perform an open label two arms, non randomized trial giving Convalescent Plasma
donated from recovered COVID-19 patients with positive serology to severe and clinical
pneumonia COVID-19 patients admitted to the ABC Medical Center.
Biological: Anti SARS-CoV 2 Convalescent Plasma in severe COVID-19 patients
Administration of Convalescent Plasma to COVID-19 obtained from donors with prior documented SARS-CoV 2 infection with IgG antibodies to hospitalized COVID-19 severe cases.
Biological: Anti SARS-CoV 2 Convalescent Plasma in critical COVID-19 patients
Administration of Convalescent Plasma to COVID-19 obtained from donors with prior documented SARS-CoV 2 infection with IgG antibodies to hospitalized COVID-19 critical cases.
Inclusion Criteria:
Donors:
1. Age: >18 and <60 years
2. Body weight : >60 kg
3. Confirmed previous SARS CoV-2 infection
4. negative SARS CoV-2 test result
5. 21 day without symptoms from the negative SARS CoV2 negative test
6. Written informed consent to participate in this clinical trial, to donate plasma and
to store the specimen for future testing.
7. Positive COVID-19 IgG antibodies
8. Male donors, or female donors who have not been pregnant, or female donors who have
been pregnant tested negative for HLA antibodies
9. Individuals who meet all regular voluntary donor eligibility requirements by the
Mexican legislation.
Patients/recipients:
1. Age: >18 years
2. Admitted to the ABC Medical Center facility for the treatment of COVID-19
3. Patients with severe or critical COVID-19
4. Informed consent provided by the patient or healthcare proxy
Exclusion Criteria:
Patients/recipients:
1. Contraindication to transfusion (severe volume overload, history of anaphylaxis to blood
products) 2. Any other not controlled infection 3. Disseminated Intravascular Coagulopathy
4. Patient under dialysis 5. Patient with recent Hemorrhagic Stroke 6. Severe Ischemic
Heart Disease
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Centro Medico Abc
Mexico City, Mexico