Timing of of corticosteroids administration is very important in COVID19 cases for the recovery and decrease the mortality.
The sickest patients with COVID-19 suffer a hyperinflammatory state-a cytokine storm-that has
features in common with a rare haematological condition called haemophagocytic
lymphohistiocytosis. Immune suppression should help such patients. By contrast, immune
suppression during the early phase of the viral infection might allow increased viral
replication and aggravate the disease.
The 3C-like proteinase on SARS-CoV-2 (nsp5) inhibits HDAC2 transport into the nucleus, and so
impairs the way in which it mediates inflammation and cytokine responses, so activation of
histone deacetylase by dexamethasone may directly oppose the action of SARS-CoV-2.
Timing of of corticosteroids administration is very important in COVID19 cases for the
recovery and decrease the mortality.
Drug: Early-Corticosteroids
early use of dexamethasone/Methylprednisolone as early as laboratory evidence of high inflammatory markers
Other Name: Array
Inclusion Criteria:
- any case with COVID-19 more than or equal to 18 years
- mild and moderate severity
Exclusion Criteria:
- Severe to critical COVID-19
- Any contra-indication for the interventional drug
- Mentally disabled cases
Asalam
Maadi, Cairo, Egypt
Emad R Issak, Principal Investigator
Assalam Clinics