Covid-19 mainly affects the respiratory system. Multiple organ dysfunction and a particularly progressive respiratory insufficiency along with a widespread coagulopathy presumed to be due to infection-associated inflammation and the resulting cytokine storm, are strongly associated with high mortality rates. In this study, the association between thrombosis risk and clinical presentation of Covid-19 is investigated.
The severe acute respiratory distress syndrome related coronavirus-2 (SARS-CoV-2) and its
clinical presentation as Coronavirus disease 2019 (COVID-19) was first reported in Wuhan,
Hubei, China in December 2019. It has spread rapidly from its origin in Wuhan City to other
countries of the world over the last several months.
Although it mainly affects the respiratory system , multiple organ dysfunction and a
particularly progressive respiratory insufficiency along with a widespread coagulopathy
presumed to be due to infection-associated inflammation and the resulting cytokine storm, are
strongly associated with high mortality rates. SARS-CoV-2 infection may also lead to
thrombotic disease both in the venous and arterial circulation of patients apart from
respiratory system due to excessive inflammation, thrombocyte activation, endothelial
malfunction, and stasis.
Investigators have reported that both CHADS2 and CHA2DS2-VASc scores were related to
mortality in individuals that had stable coronary angina, acute coronary syndrome, Takotsubo
syndrome or sick sinus syndrome, apart from atrial fibrillation . In addition,
thrombocyte/lymphocyte (PLT/LYM) and neutrophil/lymphocyte (NEU/LYM) ratios on admission were
also related with thromboembolic complications in former studies which found them useful to
predict prognosis of acute pulmonary embolism, as being one of the thromboembolic
complications of Covid-19.
Investigators suggest that the parameters mentioned above should also be studied in terms of
thrombotic complications of Covid-19. Thus they aimed to find out potential associations
between markers of prothrombotic or inflammatory conditions and some clinical features of
Covid-19 pneumonia cases on admission and follow-up.
Inclusion Criteria:
- patients diagnosed with COVID - 19 pneumonia between March 11 th , 2020 and April
25th, 2020 in the emergency, internal medicine and cardiology outpatient clinics.
- patients diagnosed by pcr testing and computed tomography of the chest
Exclusion Criteria:
- patients below 18 years of age
- patients with an alternative aetiology of pneumonia
Vital Hospital
Bahcelievler, Istanbul, Turkey