This is a collaborative study between Icahn School of Medicine at Mount Sinai, Boehringer Ingelheim Pharmaceuticals and up to 9 other clinical centers across the US to determine the effect of nintedanib on slowing the rate of lung disease in patients who have been diagnosed with COVID-19, and have ongoing lung injury more than 30 days out from their diagnosis. Required one of the following after diagnosis with SARS-CoV-2: supplemental oxygen by nasal cannula, high flow oxygen, non invasive ventilation such as CPAP or BIPAP, or mechanical ventilation or a history of desaturation below 90%.
The purpose of this study is to determine the efficacy of the study drug, nintedanib, on
slowing the rate of lung disease in patients who are noted to have infiltrates, or ongoing
lung injury, on chest x-ray/CT 30 days or longer from their initial symptoms. In addition,
the study will also investigate patient reported outcomes using questionnaires, and the
safety and tolerability of the study drug. Blood specimens will be collected to assess
biomarkers and monitor drug safety.
The trial will be randomized 1:1 between nintedanib and placebo.
Nintedanib has been approved by the FDA for the treatment of chronic fibrosing ILD with a
progressive phenotype, but has not been studied in patients with post COVID 19 lung disease.
Subjects participating in this study will:
- Attend in person visits to the study doctor's office on the date of enrollment, 15 days
after enrollment, 45 days after enrollment, 90 days after enrollment, 135 days after
enrollment, and 180 days after enrollment. If the participant is being enrolled in the
study while hospitalized, the study doctor will travel to the hospital room. There will
also be a follow-up phone call 30 days after finishing study drug.
- Undergo a HRCT (High-resolution computed tomography) scan of the chest within 6 weeks of
enrollment, and then again at 180 days after enrollment.
- Have Pulmonary Function Tests within 14 days of enrollment, and then again 45, 90, 135
and 180 days after enrollment.
- Have a six-minute walk test at baseline, day 90 and day 180 after enrollment.
- Have blood drawn routinely while participating in this study (within 14 days of
randomization, 15 days after starting medication, then again on day 45, 90, 135 and
180).
- Participants will not pay for physician visits, blood draws, breathing tests, CT scans
or the medication for this study. Participants will receive a stipend to cover the
transportation costs for your visits.
The main risks to participants are:
1. Common side effects include: nausea, vomiting, diarrhea, stomach discomfort
2. Loss of appetite and weight loss
3. Liver function abnormalities (blood work will be monitored periodic intervals at
scheduled blood draws as listed above)
4. Slightly higher risk of bleeding
5. Slightly higher risk of blood clots that can form in the blood vessels that supply
oxygen to vital organs such as the brain and heart
6. Kidney disease resulting in protein/and or albumin being lost through urine
Benefits from participation in this research include the possibility that nintedanib may slow
down/prevent progression of lung fibrosis. If the lungs can heal without fibrosis, this may
result in fewer symptoms of shortness of breath, cough and need for added oxygen.
Instead of participating in this research, subjects may choose to monitor their lung
condition with their doctor or participate in another research study.
Drug: Nintedanib
150 mg PO twice a day, taken with food food (or, for Child-Pugh A patients, 100 mg by mouth twice daily).
Drug: Placebo
placebo 150 mg equivalent twice a day, taken with food food (or, for Child-Pugh A patients, 100 mg by mouth twice daily).
Inclusion Criteria:
- Willing and able to provide written informed consent
- Subjects Age ≥ 18
- Initial SARS-CoV-2 infection confirmed by PCR test or positive serologies
- Have findings consistent with interstitial lung disease found on CT scan (these may
include ground glass opacities, reticulations, traction bronchiectasis, septal
thickening, and early honeycombing)
- Required one of the following after diagnosis with SARS-CoV-2: supplemental oxygen by
nasal cannula, high flow oxygen, non invasive ventilation such as CPAP or BIPAP, or
mechanical ventilation or a history of desaturation below 90%
- Are at least 30 days from onset of initial SARS-CoV-2 symptoms
- Forced Vital Capacity less than or equal to 90% predicted based on ATS/ERS criteria or
DLCO less than or equal to 70%
- Women of childbearing potential who agree to use of highly effective contraception
during treatment and for three months following the last dose of nintedanib
Exclusion Criteria:
Candidates will be excluded from study entry if any of the following exclusion criteria
exist at the time of the Screening Visit (prior to randomization):
- Co-administration of other investigational agents against COVID-19
- Active SARS-CoV-2 infection based on clinical judgment
- Currently Pregnant or Breast Feeding
- Current Use of Prednisone or equivalent > 10 mg/daily or immunosuppressive therapy or
disease modifying agents
- Use of full dose anticoagulation therapy or high dose anti platelet drug therapy at
screening (at the discretion of the investigator, anticoagulation therapy may be added
if clinically indicated)
- History of myocardial infarction within past 90 days
- Life threatening bleed
- Hemodynamic instability or shock
- Superimposed pulmonary bacterial infection
- Pre-existing interstitial lung disease
- Active Hep A/B/C hepatitis as measured with PCR for viral load and/or serologies
- Pre-existing liver disease: Including Abnormal Laboratory Liver Function: Childs Pugh
B/C, AST/ALT > 3 times the upper limit of normal (ULN). If Child Pugh A, can
participate on nintedanib 100 mg by mouth twice daily.
- Subjects with a Creatinine clearance <30 ml/min or currently on hemodialysis
- Inability to tolerate orally administered medication (medication must be taken with
meals)
- Patients who are in the intensive care unit (ICU) or in the step-down unit on invasive
or non-invasive mechanical ventilation, ECMO, or high flow nasal cannula oxygen, will
not be included.
- Any condition that in the opinion of the Investigator, constitute a risk or a
contraindication for the participation of the patient into the study or that could
interfere with the study objectives, conduct or evaluation.
- Patients with known hypersensitivity to nintedanib, peanut, soy, or to any of the
excipients.
Banner Health Medical University - Phoenix
Phoenix, Arizona, United States
Emory Healthcare Network
Atlanta, Georgia, United States
The Johns Hopkins Hospital
Baltimore, Maryland, United States
Mount Sinai Beth Israel
New York, New York, United States
Icahn School of Medicine at Mount Sinai
New York, New York, United States
Baylor University Medical Center Dallas
Dallas, Texas, United States
Baylor College of Medicine
Houston, Texas, United States
University of Utah
Salt Lake City, Utah, United States
ENDCOVI Study Team
646-992-7222
endcovi@mssm.edu
Maria Padilla, MD, Principal Investigator
Icahn School of Medicine at Mount Sinai