A Study to Evaluate the Safety, Tolerability, and Immunogenicity of UB-612 COVID-19 Vaccine

Inclusion Criteria:

1. Healthy male or non-pregnant female between the age of 20 and 55 years at time of
enrollment.

2. Women of childbearing potential and men must agree to practice medically effective
contraception from first vaccination until 3 months after the last vaccination.

3. Able to understand the content and possible risks of informed consent and willing to
sign the Informed Consent Form (ICF).

4. Able to understand and agrees to comply with all study procedures and be available for
all study visits.

5. Negative serological test for Hepatitis B surface antigen (HBsAg), HCV RNA and HIV
antibody screening.

6. Negative in serum antibodies (IgG) against SARS-CoV-2 ELISA.

7. Negative result of RT-PCR screening of nasopharyngeal or throat swabs for SARS-CoV-2.

8. Ear temperature ≤ 38.0°C.

9. The body mass index (BMI) of 18-30 kg/m2, inclusive, at screening.

10. Indexes of blood routine, biochemistry and other laboratory tests are within the
normal ranges, or not clinically significant as judged by investigators.

11. Judged to be healthy by the investigator on the basis of medical history, physical
examination, 12-lead ECG, vital signs, and clinical laboratory tests performed at
screening.

Exclusion Criteria:

1. History of anaphylaxis, urticarial, or other significant adverse reaction requiring
medical intervention after receipt of a vaccine.

2. Female who is pregnant or positive in pregnancy test at screening or just prior to
each vaccination administration.

3. Female who is breast-feeding or plans to breastfeed from the time of the first
vaccination through 60 days after the last vaccination.

4. Any acute illness, as determined by the study investigator 3 days before first
vaccination.

5. Evidence or history of clinically significant hematological, renal, endocrine,
pulmonary, gastrointestinal, cardiovascular, hepatic, psychiatric, neurologic, or
allergic disease.

6. Known history of SARS or MERS.

7. Previous exposure to SARS-CoV-2 or receipt of an investigational vaccine product for
the prevention of COVID-19, MERS or SARS.

8. Subjects who take part in another clinical study within 12 weeks prior to the day of
informed consent.

9. With certain underlying medical conditions which are at increased risk for severe
illness from COVID-19.

10. Congenital or acquired angioedema.

11. Immune deficiency/disorder, whether due to genetic defect, immunodeficiency disease or
immunosuppressive therapy.

12. Platelet disorder or other bleeding disorder may cause injection contraindication.

13. Prior chronic administration of immunosuppressant or corticosteroids, cytotoxic
treatment in last 6 months before first vaccination.

14. Prior administration of immunoglobulins and/or any blood products in last 4 months
before first vaccination.

15. Prior administration of attenuated, nucleic acid (mRNA or DNA) or vectored vaccines in
last 1 month before first vaccination or expectation of such vaccines in the month
after the second vaccination.

16. Prior administration of subunit vaccine or inactivated vaccine in last 14 days before
first vaccination or expectation of receipt of such vaccines in the 14 days after the
second vaccination.

17. Current anti-tuberculosis (TB) therapy or history of TB.

18. Alcoholism or substance abuser.

19. History of malignancy within 5 years prior to screening visit, except basal cell
carcinoma of the skin and cervical carcinoma in situ.

20. Any medical disease or condition that, in the opinion of the study investigator, may
confound the results of the study or pose an additional risk to the subjects by their
participation in the study.