Study to Evaluate the Safety and Efficacy of XAV-19 in Patients With COVID-19 Induced Moderate Pneumonia

Phase 2a:

Inclusion Criteria:

1. Willing and able to provide written informed consent prior to performing study
procedures

2. Male or female ≥ 18 years and ≤ 85 years

3. Hospitalized for COVID-19

4. Positive SARS-CoV-2 RT-PCR in any body specimen (nasopharynx, saliva, sputum) ≤ 10
days before enrolment

5. Evidence of pulmonary involvement (on lung examination [rales/crackles] and/or
chest-imaging [Chest X-ray or computed tomography])

6. Requiring O2 supplement ≤ 6L/min at screening

7. Requiring O2 supplementation with SpO2 ≥ 94% on O2 therapy at screening

8. First onset of COVID-19 symptoms ≤ 10 days, among fever and/or chills, headache,
myalgias, cough, shortness of breath, whichever as occurred fist

9. WOCBP must have a negative urinary pregnancy test the day of inclusion

10. All sexually active male subjects must agree to use an adequate method of
contraception throughout the study period and for 90 days after the last dose of study
drug and agree to no sperm donation until the end of the study, or for 90 days after
the last dose of XAV-19, whichever is longer

11. Patients with French social security

Exclusion Criteria:

1. Evidence of multiorgan failure (severe COVID-19)

2. Mechanically ventilated (including ECMO)

3. Receipt of immunoglobulins or any blood products in the past 30 days

4. Psychiatric or cognitive illness or recreational drug/alcohol use that in the opinion
of the investigator, would affect subject safety and/or compliance

5. End-stage renal disease (eGFR < 15 ml/min/1,73 m2)

6. Child-Pugh C stage liver cirrhosis

7. Decompensated cardiac insufficiency

8. History of active drug abuse

9. Known allergy, hypersensitivity, or intolerance to the study drug, or to any of its
components

10. Females of childbearing potential without contraceptive method, or with positive
pregnancy test, breastfeeding, or planning to become pregnant during the study period

11. Current documented and uncontrolled bacterial infection.

12. Prior severe (grade 3) allergic reactions to plasma transfusion

13. Patient participating in another interventional clinical trial

14. Life expectancy estimated to be less than 6 months

15. Patient under guardianship or trusteeship

Phase 2b:

Inclusion criteria:

1. Willing and able to provide written informed consent prior to performing study
procedures

2. Male or female ≥ 18 years

3. Hospitalized for COVID-19

4. Documentation of SARS-Cov-2 infection before enrolment, by positive SARS-CoV-2 RT-PCR
or antigen in any body specimen (nasopharynx, oropharynx, saliva, sputum,
bronchoalveolar lavage …) before enrolment

5. Evidence of pulmonary involvement (on lung examination [rales/crackles] and/or
chestimaging [Chest X-ray or computed tomography])

6. Requiring O2 supplement ≤ 6L/min at screening

7. Requiring O2 supplementation with SpO2 ≥ 92% on O2 therapy at screening (or ≥ 90

% if chronic obstructive pulmonary disease)

8. First onset of COVID-19 symptoms ≤ 14 days, among fever and/or chills, headache,
myalgias, cough, shortness of breath, whichever as occurred fist (other symptoms such
as asthenia not to be considered in this list)

9. WOCBP must have a negative urinary pregnancy test the day of inclusion

10. All sexually active male subjects must agree to use an adequate method of
contraception throughout the study period and for 90 days after the last dose of study
drug and agree to no sperm donation until the end of the study, or for 90 days after
the last dose of XAV-19, whichever is longer

11. Patients with French social security

Exclusion criteria:

1. Evidence of multiorgan failure (severe COVID-19)

2. Mechanically ventilated (including ECMO)

3. Receipt of immunoglobulins or any blood products in the past 30 days

4. Psychiatric or cognitive illness or recreational drug/alcohol use that in the opinion
of the investigator, would affect subject safety and/or compliance

5. End-stage renal disease (eGFR < 15 ml/min/1,73 m2)

6. Child-Pugh C stage liver cirrhosis

7. Decompensated cardiac insufficiency

8. Known allergy, hypersensitivity, or intolerance to the study drug, or to any of its
components

9. Females of childbearing potential without contraceptive method, or with positive
pregnancy test, breastfeeding, or planning to become pregnant during the study period

10. Current documented and uncontrolled bacterial infection.

11. Prior severe (grade 3) allergic reactions to plasma transfusion

12. Patient participating in another interventional clinical trial

13. Life expectancy estimated to be less than 6 months

14. Patient under guardianship or trusteeship

15. Patient already included

16. Prior hospitalisation in intensive care unit for the current covid-19 episode