Study Assessing the Safety, Tolerability, Pharmacokinetics, and Immunogenicity of Repeated Subcutaneous Doses of Anti-Spike (S) SARS-CoV-2 Monoclonal Antibodies (REGN10933+REGN10987) in Adult Volunteers as Related to COVID-19

Key Inclusion Criteria:

1. Is healthy or has chronic medical condition(s) that is stable and well controlled as
per the opinion of the investigator and is not likely to require medical intervention
through the end of study

2. Stable medication for co-morbid condition(s) for at least 6 months prior to screening

3. Willing and able to comply with study visits and study-related procedures, including
compliance with site precautionary requirements related to SARS-CoV-2 infection and
transmission

Key Exclusion Criteria:

1. Positive diagnostic test for SARS-CoV-2 infection ≤72 hours prior to randomization

2. Subject-reported clinical history of COVID-19 as determined by investigator

3. Subject-reported history of prior positive diagnostic test for SARS-CoV-2 infection

4. Active respiratory or non-respiratory symptoms suggestive or consistent with COVID-19

5. Medically attended acute illness, systemic antibiotics use, or hospitalization (ie,
>24 hours) for any reason within 30 days prior to screening

6. Acute exacerbation of a chronic pulmonary condition (eg, chronic obstructive pulmonary
disease [COPD], asthma exacerbations) in the past 6 months prior to screening

7. Received investigational or approved SARS-CoV-2 vaccine

8. Received investigational or approved passive antibodies for SARS-CoV-2 infection
prophylaxis as defined in the protocol

9. Use of remdesivir, intravenous immunoglobulin (IVIG), or other anti-SARS viral agents
within 2 months prior to screening

NOTE: Other protocol-defined Inclusion/ Exclusion criteria apply