Study to Assess Efficacy and Safety Relative to Standard of Care in Patients With COVID-19 Pneumonia

Inclusion Criteria:

1. Patient is a male or nonpregnant female 18 years of age or older.

2. Patient has a positive reverse-transcriptase-polymerase-chain-reaction (RT-PCR) assay
for SARS-CoV-2 in a respiratory tract sample during the current hospital admission.

3. Patient has pneumonia confirmed by chest imaging.

4. Patient has moderate to severe disease based on the WHO disease severity scale
assessment at the time of randomization defined as:

- Score 4, only those with FiO2 > 40%

- Score 5 (Non-invasive ventilation or high-flow oxygen)

5. Patient has ability to provide informed consent signed by study patient or legally
acceptable representative.

6. Patient has willingness and ability to comply with study-related
procedures/assessments

Exclusion Criteria:

1. Has an active malignancy or history of solid or hematological malignancies within 5
years prior to enrollment in the study. Patients who had basal or squamous cell
carcinoma-in-situ of the skin that was diagnosed > 2 years prior to the study
enrollment and not currently being treated are eligible for study enrollment.

2. Patient is pregnant or breast-feeding.

3. Patient, in the opinion of the investigator, is unlikely to survive for ≥48 hours from
the time of screening.

4. Patient has any physical examination findings and/or history of any illness that, in
the opinion of the study investigator, might confound the results of the study or pose
an additional risk to the patient by their participation in the study.

5. Patient with alanine aminotransferase (ALT) or aspartate transaminase (AST) > 3x upper
limit of normal (ULN) and/or total bilirubin > 2xULN at baseline

6. Patient requires treatment with the cytochrome P450 1A2 (CYP1A2) inhibitors,
ciprofloxacin (Cipro®) and/or fluvoxamine (Luvox®)

7. Patients participating in any other clinical trial with an investigational drug
product or procedure

8. Recipients of solid organ and/or hematopoietic cell transplantation

9. Patient is known to have End Stage Renal Disease (ESRD) and was being treated with
maintenance hemodialysis or peritoneal dialysis prior to the current hospitalization.

Note: Patients who initiated RRT due to Acute Kidney Injury during their current
hospitalization will be eligible for the study