This study investigate the kinetics of IgG responses to both N and S proteins in the subjects who suffered from COVID 19 and then had recovered.
Coronaviruses (CoVs) are enveloped, single positive-strand RNA viruses belonging to the large
subfamily Coronavirinae, which can infect mammals and several other animals.The continued
spread of coronavirus disease 2019 (COVID-19) has prompted widespread concern around the
world, and the World Health Organization (WHO), on 11 March 2020, declared COVID-19 a
pandemic. Studies on severe acute respiratory syndrome (SARS) and Middle East respiratory
syndrome (MERS) showed that virus-specific antibodies were detectable in 80-100% of patients
at 2 weeks after symptom onset. Currently, the antibody responses against SARS-CoV-2 remain
poorly understood and the clinical utility of serological testing is unclear Little is known
about the kinetics, tissue distribution, cross-reactivity and neutralization antibody
response in COVID-19 patients .
The seropositivity rate of both IgM and IgG responses after onset and recovery of disease,
and in the context of both N protein and S protein has not been clarified. The kinetics of
antibody responses in critical cases or ICU patients has not been reported, and no studies
have suggested whether antibody response is associated with disease prognosis
Diagnostic Test: IgG SARS CoV2
IgG SARS CoV 2 will be checked in serum of COVID 19 recovered population
Inclusion Criteria:
Subjects recovered from COVID 19 confirmed on PCR or clinically
Exclusion Criteria:
subjects who have not been confirmed suffering from COVID 19 by PCR or clinically
Lahore General Hospital
Lahore, Punjab, Pakistan
Amina Asif, MPhilMicro, Principal Investigator
LahoreGeneralHospital.Lahore