The aim of this study is to apply serology testing methods for SARS-CoV2 antibodies insamples collected from HCWs in an acute hospital. This will enable the identification ofthose who are protected and non-infectious for SARS-CoV2 and those who are seronegativeand therefore potentially susceptible and infectious on patient contact. Prospectivetesting will provide data on the acquisition of SARS-CoV2 infections among HCWs andassociated risk factors for transmission during a pandemic at an acute care hospitalfacility in the capital region of Denmark.Hypothesis: Serial seroconversion measurements in hospital employees improve theorganization of the clinical treatment and care during the COVID-19 pandemic atNordsjællands Hospital and Nykøbing Falster County Hospital.
The study is a prospective cohort study. Weekly (in the first phase) and bi-weekly (in
the second phase) serum samples will be drawn and shipped bi-weekly to laboratory
collaborators in United Kingdom for antibody analyses during the course of the local
epidemic, expected to last 10-12 weeks or more. After the cease of the epidemic serum
will be drawn in 3-monthly intervals in a smaller group of seroconverted volunteers to
follow the long-lasting immunity of SARS-CoV-2 infection up to 5 years post-pandemic.
Nurses, medical doctors, biomedical laboratory scientists, social health care assistants,
and few healthcare administrators (as controls) will be invited for enrolment. In
hospitals, all departments with staff that are in physical contact with patients during
the pandemic will be invited to participate in the study.
Other: Serial seroconversion measurements in hospital employees during the COVID-19 pandemic
The aim of this study is to apply serology testing methods for SARS-CoV2 antibodies in
samples collected from HCWs in an acute hospital.
Inclusion Criteria: hospital employee
- Exclusion Criteria: none
Nordsjællands Hospital
Hillerød, Capital Region, Denmark
Nykøbing Falster County Hospital
Nykøbing Falster, Southern Region, Denmark
Fischer
+45 2440 1718
thea.koelsen.fischer@regionh.dk
Thea K Fischer, professor, Principal Investigator
Nordsjællands Hospital