SARS-CoV-2, one of a family of human coronaviruses, was initially identified in December 2019 in Wuhan city. This new coronavirus causes a disease that has now been named COVID-19. The virus has subsequently spread throughout the world and was declared a pandemic by the World Health Organisation on 11th March 2020. As of April 1, 2020, there are 874.081 numbers of confirmed cases with 43.290 fatalities. There is no approved therapy for COVID-19 and the current standard of care is supportive treatment. Key markers implying a fatal outcome are acute respiratory distress syndrome (ARDS)-like disease with pronounced dyspnea, hypoxia and radiological changes in the lung. Senicapoc improves oxygenation and reduces fluid retention, inflammation, and bleeding in the lungs of mice with ARDS-like disease. In cells, there is an antiviral effect of senicapoc.
The investigators discovered that in an animal model with a knockout of a potassium channel
with intermediate conductance (KCa3.1), the knockout protected against lung damage and
accumulation of liquid in the lung. In subsequent studies, the investigators have developed a
mouse model showing that genetic deletion of the KCa3.1 channels and senicapoc, a blocker of
KCa3.1 channels, protects against the accumulation of liquid in the lung. Moreover, senicapoc
treatment possesses anti-inflammatory effects illustrated as lower leukocyte accumulation
inside the lungs after injury. Importantly, it also increases the FiO2/PaO2 ratio (ratio of
inhaled to blood oxygen), hence preserving lung function in mice with an ARDS-like disease.
In addition, there is evidence that senicapoc has antiviral properties. Aarhus University has
patented senicapoc for use in the treatment of acute respiratory disease. In this case,
respiratory disease is caused by an infection with a coronavirus. Senicapoc has been
developed for the treatment of sickle cell disease and has been administered to 500 patients
without observation of major treatment-related adverse effects.
Drug: Senicapoc
The intervention will consist of 50 mg enteral senicapoc administered as soon as possible after randomization and again after 24 hours
Other Name: ICA-17043
Inclusion Criteria:
- COVID-19 positive
- Age ≥18 years
- Respiratory insufficiency
- ICU admission
Exclusion Criteria:
- Severe heart failure (ejection fraction < 30%)
- Severe renal insufficiency (eGFR < 30 mL/min/1.73m2)
- Severe hemodynamic instability (noradrenalin dose > 0.3 μg/kg/min)
- Prior enrollment in the trial
- Pregnancy
- Allergy to senicapoc
- Inability to take enteral medication
- More than 24 hours since ICU admission
- Limitations of care
- Anticipated death within 24 hours
Aalborg University Hospital
Aalborg, Denmark
Aarhus University Hospital
Aarhus, Denmark
Hvidovre Hospital
Hvidovre, Denmark
Odense University Hospital
Odense, Denmark
Ulf Simonsen, MD, PhD
+4560202613
us@biomed.au.dk
Asger Granfeldt, MD, PhD
covipoc@clin.au.dk