The main objectives of this study are 1) to establish the prevalence of SARS-CoV-2 in asymptomatic healthcare workers (HCWs) in an early phase of community spread as well as 2) to monitor the future spread of the disease by assessing serological responses to SARS-CoV-2 in symptomatic and asymptomatic HCWs over time and 3) to improve the assessment of the immune response and its protective effect as well as the assessment of infectivity of affected HCWs and 4) to evaluate the value and significance of antibody formation and serological antibody tests and 5) to be able to evaluate possible future preventive and / or therapeutic approaches against SARS-CoV-2, e.g. to assess vaccination effects
This study aims to collect information on staff working at the Greifswald University
hospital.
Over a 5 year period, a maximum of 12 study visits per participant are planned. At each
visit, nasal/throat swabs (for PCR testing) and/or blood samples (to assess immunological
responses, e.g. for SARS-CoV-2 antibody testing) will be collected. This will help to gain a
better understanding of viral load and immunological responses, e.g. antibody development and
their effects over time.
At study visit 2 - 12, participants will also be asked to fill in a questionnaire (asking for
SARS-CoV-2 risk factors, perceived risk, impact of the pandemic on their quality of life,
their interest in getting a SARS-CoV-2 vaccine/their SARS-CoV-2 vaccination status and
vaccination side effects).
The remaining blood samples will be stored in a repository for future research.
The study is part of a modular SARS-CoV-2-research programme of the University Medicine
Greifswald.
Diagnostic Test: Nasal swab
SARS-CoV-2 PCR
Diagnostic Test: Serum testing
Anti-SARS-CoV2 S protein IgG ELISA, serological changes after SARS-CoV-2 vaccination
Inclusion Criteria:
1. >= 18 years of age
2. Willing and able to complete a written consent form
3. Willing to have blood samples stored for future research
4. Healthcare worker employed at Greifswald University Hospital
Exclusion Criteria:
1. < 18 years of age
2. Decline to participate
Greifswald University Medicine
Greifswald, Germany