This is a Phase 1/2a clinical trial to assess the safety and immunogenicity of AdCLD-CoV19 in healthy adults.
Part A is conducted as dose-escalation, single-center, open-label, a Phase 1 clinical trial.
Part B is conducted as multi-center, open-label, a Phase 2a clinical trial. In Part A, we
assess safety in all dose groups and set suitable two doses for Part B. In Part B, we assess
immune responses against SARS-CoV-2 and set suitable dose for next phase of clinical trial.
DSMB will evaluate safety during the whole study period.
Biological: AdCLD-CoV19
Replication-defective human adenovirus type 5/35 vector based vaccine expressing S protein of SARS-CoV-2.
Inclusion Criteria:
1. Able and willing to agree informed consent and aged 19 to 64 years.
2. The BMI index is 18.5 kg/m2 to 30.0 kg/m2.
3. Weigh 40kg to 100kg (Part A only)
4. Able and willing to medically effective contraception during the whole study period.
5. Agreement to refrain from blood donation during the whole study period.
Exclusion Criteria:
1. Anyone deemed infected by COVID-19.
2. Determined to be a close-contact of SARS-CoV-2 confirmed case or classified to
symptomatic patient of COVID-19 prior to vaccination.
3. Clinically significant abnormal ranges of laboratory measurement, ECG, Chest X-ray at
screening visit.
4. Positive in HIV, HBV, HCV test at screening visit.
5. Acute fever(≥ 38℃) or suspected infectious disease, symptoms of infectious
disease(cough, difficulty breathing, chills, muscle aches, headache, sore throat, loss
of smell, or loss of taste, etc.) within 3 days prior to vaccination.
6. Chronic respiratory disease: Asthma, chronic obstructive pulmonary disease, active
tuberculosis, latent tuberculosis under treatment.
7. Clinically significant active or any history of disease: Hepatobiliary system, kidney,
central or peripheral nervous system (epilepsy, seizure, etc.), endocrine system
(uncontrolled diabetes, hyperlipidemia, etc.), cardiovascular system (congestive heart
failure, coronary artery disease, myocardial infarction, control Hypertension, etc.),
blood tumor, urinary system, mental, musculoskeletal system, immune system (rheumatoid
arthritis, systemic lupus erythematosus).
8. Immunosuppressive disease including immunodeficiency disease.
9. Scheduled to undergo any surgery during the whole study period.
10. Healthcare worker who provide medical care to SARS-CoV-2 cases or occupationally in
high risk for SARS-CoV-2 exposure during the whole study period.
11. Prisoners or subjects who are compulsorily detained. (involuntary incarceration)
12. History of SARS or MERS.
13. Allergic reaction or hypersensitivity to any ingredient of AdCLD-CoV19.
14. Having hemophilia at risk of causing serious bleeding when injected intramuscularly or
receiving anticoagulants.
15. Any history of malignant disease within the past 5 years.
16. History of hypersensitivity to inoculate vaccine such as Guillain-Barre syndrome.
17. History of serious adverse reaction or allergic reaction to inoculate vaccine.
18. Urticaria past 5 years prior to vaccination.
19. History of hereditary angioneurotic edema or acquired angioneurotic edema.
20. History of solid organ or bone marrow transplantation.
21. Suspected or a history of drug or alcohol abuse past 12 month before vaccination.
22. Receipt of vaccine of SARS-CoV, MERS-CoV, SARS-CoV-2.
23. Receipt of adenovirus vector based vaccine.
24. Chronic use of immunosuppressant or immune modifying drug within 6 months prior to
vaccination. (use of inhaled, topical, nasal, and ophthalmic corticosteroids are
allowed)
25. Having relied on antipsychotic drugs and narcotic analgesics within 6 months before
vaccination or difficult to comply with the clinical trial procedure at the judgment
of the investigator.
26. Administered to other investigational product or medical device within 6 months before
vaccination.
27. Other vaccination history within 30 days prior to vaccination or being scheduled
within 30 days after vaccination.
28. Receipt of immunoglobulin or any blood product within 3 month prior to vaccination.
29. Pregnant(including positive hCG test at screening visit) or breastfeeding female.
30. Current smoker or vaper. (use of cigarette or e-cigarette at least once in last 30
days, Part A only)
31. Those who are directly related to the investigator.
32. Other condition deemed ineligible for the study at the discretion of investigator.
Korea University Ansan Hospital
Ansan, Province, Korea, Republic of
The Catholic University of Korea, ST. Vincent's Hospital
Suwon, Province, Korea, Republic of
Hallym University Kangnam Sacred Heart Hospital
Seoul, State, Korea, Republic of
The Catholic University of Korea, Seoul ST. Mary's Hospital
Seoul, State, Korea, Republic of
Korea University Guro Hospital
Seoul, Korea, Republic of