Official Title
Ambulatory Respiratory Tract Infection Survey, Burden of Respiratory Syncitial Virus in the Era of Covid-19
Brief Summary

Strengthening outpatient low respiratory tract infection surveillance to document the burden of Respiratory Syncytial Virus (RSV)

Detailed Description

The study protocol is designed with three key components: 1. Build on existing PARI
outpatient syndromic surveillance by adding laboratory multiplex testing of LRTI samples
(RSV, Influenza, SARS-COV-2) 2. Follow all bronchiolitis through the PARI RWE database and
document "patient journey" for 5 years after first medical visit 3. Review the electronic
PARI data of three previous seasons in order to document the impact of LRTI attributable to
RSV in children < 2 years in France prior to enhanced surveillance

Recruiting
RSV Infection
Children, Only
Outpatient
Bronchiolitis
Otitis Media
Pneumonia

Diagnostic Test: nasopharyngeal samples

rapid antigen test for Sars Cov-2, influenza and RSV. multiplex RT-PCR for a subgroup of 500 patients

Eligibility Criteria

Inclusion Criteria:

- children under 24 months of age (≤)

- One of the holders of parental authority signed the consent

- Patient affiliated to a social security scheme (Social Security or Universal Medical
Coverage)

- First episode of bronchiolitis defined by

- Age ≤24 months

- At least one symptom from group A and one symptom from group B Group A (one or more)

- Fever >38 °C

- Cough

- Otalgia

- Nasal congestion

- Rhinorrhea

- Coryza

- Dysphagia Group B (one or more)

- whistling

- Crackles

- Rales

- Decrease in respiratory noise

- Shortness of breath

- Dyspnea

- OR Acute purulent otitis media (Paradise Criteria) or otorrhea.

- OR Pneumonia defined by the presence of opacity of parenchymal condensation and/or
pleural effusion on chest X-ray associated with fever

Exclusion Criteria:

- Age >24 months

- Refusal by one of the parents

- Not affiliated to a social security system

Eligibility Gender
All
Eligibility Age
Minimum: 1 Day ~ Maximum: 24 Months
Countries
France
Locations

ACTIV
Créteil, France

Investigator: Corinne Levy, MD
Contact: 0033148850404
corinne.levy@activ-france.fr

Contacts

Corinne Levy, MD
0033148850404
corinne.levy@activ-france.fr

Stéphane Béchet, MsC
0033148850404
stephane.bechet@activ-france.fr

NCT Number
Keywords
RSV
Children
bronchiolitis
otitis
Pneumonia
MeSH Terms
Infections
Pneumonia
Bronchiolitis
Respiratory Syncytial Virus Infections
Otitis
Otitis Media