Recent studies have shown that some individuals may be asymptomatic but continue to shedthe COVID-19 virus. These individuals may represent a population that can unknowinglytransmit the virus. Healthcare workers (HCW) may acquire COVID-19 from the community orfrom possibly infected patients. It is important to gather data with respect to this tofurther understand the prevalence of asymptomatic carriage in individuals who work inresearch facilities, offices and clinical areas of hospitals and researchfacilities/institutes since this has important implications for infection control, aswell as staff and patient safety. The purpose of this study is to test whether aproportion of these individuals may be asymptomatic shedders of the COVID-19 virus.
Healthcare workers of participating institutions who agree to be participants will:
- Fill out some information about participants into a database portal system.
Participants will have the ability to check their COVID-19 test results via the
portal.
- Have nasopharyngeal (NP) swabs done for COVID-19 testing. This can be done about
once a week for up to 8 weeks (about 1-8 swabs total).
- Provide optional blood samples to look for COVID-19 specific antibodies and/or
proteins at the time of enrollment and after 8 weeks.
- Fill out questionnaires about participant exposures and travel history, occupation
category, any symptoms in the past 21 days, whether they have provided any
face-to-face care of a known COVID-19 positive patients in past 14 days or if
participants have any children at home who are less than 12 years of age.
- Fill out an optional questionnaire about their mental health
- Be contacted by telephone if participants are tested positive, to determine whether
participants have symptoms of COVID-19, and for the results of any follow-up
COVID-19 testing that may have been done.
Diagnostic Test: Nasopharyngeal swab
Nasopharyngeal swab for COVID-19
Other: Questionnaire collection
Fill out questionnaires regarding exposures and travel history, occupation category, any
symptoms in the past 21 days, any face-to-face care of a known COVID-19 positive patients
in past 14 days or any children at home who are less than 12 years of age.
Other: Optional blood completion
Provide blood samples to look for COVID-19 specific antibodies and/or proteins at the
time of enrollment and after 8 weeks.
Other: Optional questionnaire completion
Fill out an optional mental health questionnaire.
Inclusion Criteria:
- Individuals who work within a food production, healthcare, research or clinical
organization.
- Asymptomatic as per daily screening.
- No contraindication to performing a NP swab.
Exclusion Criteria:
- Any individual with fever, respiratory or flu-like symptoms will not be eligible.
Symptom positive individuals who were not picked up at entry screening will be
referred to their Occupational Health. Specific symptoms include:
- Fever, chills or headache
- New or worsening cough
- Shortness of breath, difficulty breathing, sore throat or difficulty swallowing
- Runny nose or stuffy nose without another cause (e.g. allergies)
- Nausea/vomiting, diarrhea, stomach pain
- Decrease/loss of taste or smell
- Unexplained fatigue, malaise, muscle aches
- Eye pain or pink eye In addition to those symptoms listed above, individuals
should also be screened for symptoms as per their institutional requirements.
- Enrolled in a COVID-related interventional study (eg. Behavioural or drug study).
University Health Network
Toronto, Ontario, Canada
Amit M Oza, MD, Principal Investigator
University Health Network, Toronto