Severe acute respiratory syndrome coronavirus 2 (COVID-19) poses substantial challenges for health care systems. With a vastly expanding amount of publications on COVID-19, clinicians need evidence synthesis to produce guidance for handling patients with COVID-19.
. Conavirus belongs to the subfamily of Ortho-coronavirinae in the family of Coronaviridae
and the Order Nidovirales. In 2003, a SARS-CoV had caused the out- break of severe acute
respiratory syndrome. In December 2019, an "unknown viral pneumonia" out- break has been
reported. Finally, a novel coronavirus was detected, isolated virus was termed as SARS-CoV2,
characterized as highly contagious and deadly. By the end of February 2020, more than 78,631
cases infected with SARS-CoV-2, and more than 2747 deaths were confrmed in China, and the
COVID-19 has been declared a pan- demic by World Health Organization. For those infected by
SARS-CoV-2, some of the patients didnot show hypoxemia or respiratory stress during the
course of COVID-19, indicating a multifaceted disease of SARS-CoV-2 infection. Therefore, one
reliable and convenient biomarker is needed to predict the severity of COVID-19 pneumonia.
Recently, several studies have reported that C-reactive protein (CRP) is positively
asso-ciated with severe dengue infection, and patients with higher plasma CRP in the initial
period of dengue, are at higher risk to develop plasma leakage. We examined which routine
laboratory tests are associated with severe COVID-19 disease, and the relation between the
laboratory results and the security of COVID19 diasease, in two of large Upper Egypt medical
centers, which are Aswan University and assiut university hospitals.
Diagnostic Test: D-dimer,CBC.ESR,CRP,
Complete blood count (for patients and control subjects): was done on CELL-DYN 3700 (Abbott-Germany) and blood film was stained by leishman staining, the morphology of red blood cells. CRP titre estimation by latix method .ESR erythrocyte sedimentation rate estimation (1:5) by Westerngreen tube method.
Diagnostic Test: Liver function tests ,serum ferritin and PCR for COVID-19 .
Serum ferritin was performed for all subjects on Modular P auto analyzer (Roche Diagnostics, Mannheim, Germany),
• Liver function tests ( aspartate aminotransferase, alanine aminotransferase and alkaline phosphatase) and kidney funcrion were performed for all subjects on Modular P auto analyzer (Roche Diagnostics, Mannheim, G ermany),
Inclusion Criteria:
- Age: all ages.
- Sex: Males and females.
- COVID-19 patients approved by positive PCR.
Exclusion Criteria:
- Patients with known chronic chest disease preceding the infection.
Anwar M. Ali, Doctorate
01030361010
anwarmoha2006@yahoo.com
Ghydaa A. Shehata, Doctorate