The co-primary objectives of this study are to: 1. Determine and compare the COVID-19 antibody positivity rate in health care workers and patients without a known COVID-19 infection 2. Determine if PCR negativity for COVID-19 early in quarantine predicts negativity at Day 14 in quarantining individuals
This is a prospective cohort study designed to identify the prevalence of IgG antibodies to
SARS CoV-2 as well as to assess risk factors for IgG positivity. It will compare rates of
positivity and risk factors among healthcare workers and non-healthcare workers and assess
the ability of PCR negativity at day 3 or 4, 5, 7, or 10 to predict negativity on day 14 in
individuals quarantining after a COVID exposure.
In addition to having a standard of care clinical antibody test, both healthcare workers,
quarantining individuals, and patients will be asked to fill out a survey to assess risk
factors for COVID infection and provide a research blood sample. Quarantining individuals
will also have standard of care PCR testing on days 3 or 4, 5, 7, 10, and 14 of the
quarantine period.
Collected blood samples will be used to assess for the presence of neutralizing antibodies
and measure antibodies with a research test. An annual blood specimen and survey will be
collected from each study participant for up to 2 years total after study entry.
Inclusion Criteria:
- Individuals (health-care workers and patients) undergoing standard of care assessment
of SARS-CoV-2 serology testing
- Individuals with a COVID-19 exposure requiring quarantine who are asymptomatic and who
will receive standard of care SARS-CoV-2 PCR testing.
- Able to understand and sign the Informed Consent and Research Authorization From.
Exclusion Criteria:
- Prisoners
- Patients with psychiatric illness that would limit compliance
- Patients with social situations that would limit compliance
University of Kentucky
Lexington, Kentucky, United States