This study is an adaptive, randomized, open-label, controlled clinical trial utilizing an adaptive design to compare effects of repurposed drugs with local standard of care alone on major inpatient hospital outcomes. This is performed worldwide in collaboration with WHO.
Drug: Remdesivir
Two intravenous loading doses, then daily infusion for 10 days
Drug: Hydroxychloroquine
Two oral loading doses, then orally twice daily for 10 days
Drug: Lopinavir / Ritonavir
Orally twice daily for 14 days
Drug: Interferon beta-1a
Daily injection for 6 days
Drug: Acalabrutinib
Orally twice daily for 10 days
Inclusion Criteria:
- Consenting adults (age ≥18) hospitalised with the following criteria will be included
in the study:
1. Probable or confirmed COVID-19 regardless of severity, i.e., mild, moderate and
severe cases
2. Not already receiving any of the study drugs
3. Without known allergy or contraindications to any of the study drugs (in the view
of the physician responsible for their care), and
4. Without anticipated transfer within 72 hours to a non-study hospital.
Exclusion Criteria:
- Patients with contraindications to any of the study drugs.
Baguio General Hospital
Baguio City, Benguet, Philippines
Cebu Doctor's University Hospital
Cebu City, Cebu, Philippines
Perpetual Succor Hospital Cebu
Cebu City, Cebu, Philippines
Vicente Sotto Memorial Medical Center
Cebu City, Cebu, Philippines
Southern Philippines Medical Center
Davao City, Davao, Philippines
West Visayas University Medical Center
Iloilo City, Iloilo, Philippines
Makati Medical Center
Makati City, Metro Manila, Philippines
Chinese General Hospital
Manila, Metro Manila, Philippines
Manila Doctors Hospital
Manila, Metro Manila, Philippines
ManilaMed - Medical Center Philippines
Manila, Metro Manila, Philippines
San Lazaro Hospital
Manila, Metro Manila, Philippines
UP - Philippine General Hospital
Manila, Metro Manila, Philippines
Asian Hospital and Medical Center
Muntinlupa, Metro Manila, Philippines
Research Institute for Tropical Medicine
Muntinlupa, Metro Manila, Philippines
San Juan de Dios Educational Foundation Inc - Hospital
Pasay, Metro Manila, Philippines
The Medical City
Pasig City, Metro Manila, Philippines
Diliman Doctors Hospital
Quezon City, Metro Manila, Philippines
Fe Del Mundo Medical Center
Quezon City, Metro Manila, Philippines
Lung Center of the Philippines
Quezon City, Metro Manila, Philippines
St Luke's Medical Center Quezon City
Quezon City, Metro Manila, Philippines
University of the East Ramon Magsaysay Memorial Medical Center
Quezon City, Metro Manila, Philippines
World Citi Medical Center
Quezon City, Metro Manila, Philippines
Cardinal Santos Medical Center
San Juan, Metro Manila, Philippines
St Luke's Medical Center Global
Taguig, Metro Manila, Philippines
Batangas Medical Center
Batangas, Philippines