Official Title
An International Randomized Trial of Additional Treatments for COVID-19 in Hospitalized Patients Who Are All Receiving the Local Standard of Care Philippines
Brief Summary

This study is an adaptive, randomized, open-label, controlled clinical trial utilizing an adaptive design to compare effects of repurposed drugs with local standard of care alone on major inpatient hospital outcomes. This is performed worldwide in collaboration with WHO.

Completed
COVID19

Drug: Remdesivir

Two intravenous loading doses, then daily infusion for 10 days

Drug: Hydroxychloroquine

Two oral loading doses, then orally twice daily for 10 days

Drug: Lopinavir / Ritonavir

Orally twice daily for 14 days

Drug: Interferon beta-1a

Daily injection for 6 days

Drug: Acalabrutinib

Orally twice daily for 10 days

Eligibility Criteria

Inclusion Criteria:

- Consenting adults (age ≥18) hospitalised with the following criteria will be included
in the study:

1. Probable or confirmed COVID-19 regardless of severity, i.e., mild, moderate and
severe cases

2. Not already receiving any of the study drugs

3. Without known allergy or contraindications to any of the study drugs (in the view
of the physician responsible for their care), and

4. Without anticipated transfer within 72 hours to a non-study hospital.

Exclusion Criteria:

- Patients with contraindications to any of the study drugs.

Eligibility Gender
All
Eligibility Age
Minimum: 18 Years ~ Maximum: N/A
Countries
Philippines
Locations

Baguio General Hospital
Baguio City, Benguet, Philippines

Cebu Doctor's University Hospital
Cebu City, Cebu, Philippines

Perpetual Succor Hospital Cebu
Cebu City, Cebu, Philippines

Vicente Sotto Memorial Medical Center
Cebu City, Cebu, Philippines

Southern Philippines Medical Center
Davao City, Davao, Philippines

West Visayas University Medical Center
Iloilo City, Iloilo, Philippines

Makati Medical Center
Makati City, Metro Manila, Philippines

Chinese General Hospital
Manila, Metro Manila, Philippines

Manila Doctors Hospital
Manila, Metro Manila, Philippines

ManilaMed - Medical Center Philippines
Manila, Metro Manila, Philippines

San Lazaro Hospital
Manila, Metro Manila, Philippines

UP - Philippine General Hospital
Manila, Metro Manila, Philippines

Asian Hospital and Medical Center
Muntinlupa, Metro Manila, Philippines

Research Institute for Tropical Medicine
Muntinlupa, Metro Manila, Philippines

San Juan de Dios Educational Foundation Inc - Hospital
Pasay, Metro Manila, Philippines

The Medical City
Pasig City, Metro Manila, Philippines

Diliman Doctors Hospital
Quezon City, Metro Manila, Philippines

Fe Del Mundo Medical Center
Quezon City, Metro Manila, Philippines

Lung Center of the Philippines
Quezon City, Metro Manila, Philippines

St Luke's Medical Center Quezon City
Quezon City, Metro Manila, Philippines

University of the East Ramon Magsaysay Memorial Medical Center
Quezon City, Metro Manila, Philippines

World Citi Medical Center
Quezon City, Metro Manila, Philippines

Cardinal Santos Medical Center
San Juan, Metro Manila, Philippines

St Luke's Medical Center Global
Taguig, Metro Manila, Philippines

Batangas Medical Center
Batangas, Philippines

University of the Philippines
NCT Number
Keywords
Solidarity
hydroxychloroquine
Lopinavir+Ritonavir
Interferon Beta 1a
Remdesivir
MeSH Terms
COVID-19
Interferons
Ritonavir
Lopinavir
Interferon-beta
Interferon beta-1a
Remdesivir
Hydroxychloroquine
Acalabrutinib