Psychological Impact of COVID-19 Quarantine and Worsening of Cardiovascular Risk in the French General Population

In response to the COVID-19 outbreak, the French government put in place home quarantine of
the general population in order to limit the transmission of the virus. It is obvious that
quarantine at home have a psychological impact which could worsened cardiovascular risk. Our
aim is to assess risk factors for severe stress, anxiety or depression, during and after
quarantine, as well as risk factors (including stress, anxiety or depression), in the
worsening of cardiovascular risk.

A prospective epidemiological observational cohort study will be carried out (in French
general population aged 50 to 89 years) with data collection by telephone interviews (in
agreement with the context of quarantine).

The telephone interviews will be carried out during quarantine (V1), in the month following
the end of quarantine (V2) and then, at 6 (V3) and 12 (V4) months. At baseline, the
questionnaire will focus on socio-demographic and contextual characteristics related to the
COVID-19 outbreak, medical history, cardiovascular risk factors and treatments, anxiety and
depression scales. Next (after the quarantine), the questionnaire will focus on the evolution
of cardiovascular risk factors and the occurrence of acute cardiovascular events, the
evolution of treatments and post-traumatic stress, anxiety or depression scales.

The assessment of risk factors for severe stress, anxiety or depression, during and after
quarantine, as well as risk factors of the worsening of cardiovascular risk will be based on
mixed logistic regression.