Official Title
Prospective Study of Persistent Dyspnea in Recovered COVID-19 Patients
Brief Summary

We conducted a national, single center (Hospital Clínico Universitario de Valladolid, Spain, Valladolid), prospective study of patients with prior hospitalization because of COVID-19 who were admitted between March 1st, 2020, and May 15th, 2020. All eligible patients underwent at least at first-time follow-up from the index event. Exclusion criteria were age < 18 years old, pregnant women, terminally ill patients, active SARS-CoV-2 infections, inability to exercise and previous known severe pulmonary or heart disease. Patients underwent a clinical assessment for symptom burden, questionnaire for quality of life (Kansas City Cardiomyopathy Questionnaire and SF-36), venous blood sampling, 6-minute walking test (6-MWT), tests of lung function (spirometry and diffusing capacity of the lungs for carbon monoxide) and treadmill cardio-pulmonary exercise testing (CPET). 48-hours before the test of lung function and the CPET, all patients yielded a negative result in the reverse transcription-polymerase chain reaction (RT-PCR) for SARS-CoV-2. For definitive analysis patients were assigned to the control group if they did not refer dyspnea at the time of the follow-up, a small asymptomatic out-patient control group without prior hospitalization was also included.

Completed
COVID19
Dyspnea

Diagnostic Test: Cardiopulmonary exercise test

Only diagnostic tests
Other Name: Array

Eligibility Criteria

Inclusion Criteria:

- Signed Informed Consent

- Previous COVID-19 hospitalization with successful discharged

- Availability of at least one follow up per clinical protocol

Exclusion Criteria:

- pregnant women

- terminally ill patients

- active SARS-CoV-2 infections

- inability to exercise

- previous known severe pulmonary or heart disease

Eligibility Gender
All
Eligibility Age
Minimum: 18 Years ~ Maximum: N/A
Countries
Spain
Locations

Hospital Clínico Universitario de Valladolid
Valladolid, Spain

Hospital Clínico Universitario de Valladolid
NCT Number
Keywords
dyspnea
COVID19
Cardiopulmonary exercise test
MeSH Terms
COVID-19
Dyspnea