Official Title
Short-term Effects of Prone Positioning on Tissue Oxygen Saturation, Measured by Near-infrared Spectroscopy, in COVID-19 Patients With Acute Respiratory Distress Syndrome
Brief Summary

The purpose of this study is to monitor short-term changes in tissue oxygen saturation and local blood flow as results of changing from supine to prone position in ARDS COVID-19 patients

Detailed Description

After obtaining consent to participate in the study, the subjects included in the study will
undergo a baseline 15-minute measurement of tissue oxygen saturation (StO2) measured
non-invasively on the forearm by means of near-infrared spectroscopy (NIRS). Once a baseline
stable StO2 value is obtained, a provocative test, consisting of a transient vascular
occlusion, will be performed. The test will allow the obtention of a local metabolic rate,
and a StO2 recovery rate after the ischemic stimulus.

Tissue oxygenation measurements will be performed in supine position, immediately before
changing to prone positioning, and repeated after 20 minutes of stabilization, once in prone
position.

Recruiting
COVID19
ARDS, Human
Eligibility Criteria

Inclusion Criteria:

- COVID-19 patients admitted in the ICU receiving invasive mechanical ventilation and
requiring prone positioning for severe hypoxemia management, as decided by the medical
team

Exclusion Criteria:

- Severe peripheral vasculopathy

- Raynaud's syndrome

- Skin lesions/trauma in upper limbs interfering the placement of the NIRS probe and/or
the occlusion tourniquet

- Deep venous thrombosis in the upper limbs

Eligibility Gender
All
Eligibility Age
Minimum: 18 Years ~ Maximum: N/A
Countries
Brazil
Mexico
Spain
Locations

Hospital de Clñinicas da UNICAMP
Campinas, Sao Paulo, Brazil

Hospital General de México
México, Mexico

Parc Taulí Hospital Universitari
Sabadell, Barcelona, Spain

Hospital Clínic i Provincial de Barcelona
Barcelona, Spain

Hospital Parc Salut Mar
Barcelona, Spain

Hospital Vall d'Hebron
Barcelona, Spain

Contacts

Jaume Mesquida, MD, PhD
+34 937231010 - 21155
jmesquida@tauli.cat

Jaume Mesquida, Principal Investigator
Parc Taulí Hospital Universitari

Corporacion Parc Tauli
NCT Number
Keywords
Covid-19
Tissue oxygenation
ARDS
Prone position
MeSH Terms
COVID-19
Respiratory Distress Syndrome