The purpose of this study is to monitor short-term changes in tissue oxygen saturationand local blood flow as results of changing from supine to prone position in ARDSCOVID-19 patients
After obtaining consent to participate in the study, the subjects included in the study
will undergo a baseline 15-minute measurement of tissue oxygen saturation (StO2) measured
non-invasively on the forearm by means of near-infrared spectroscopy (NIRS). Once a
baseline stable StO2 value is obtained, a provocative test, consisting of a transient
vascular occlusion, will be performed. The test will allow the obtention of a local
metabolic rate, and a StO2 recovery rate after the ischemic stimulus.
Tissue oxygenation measurements will be performed in supine position, immediately before
changing to prone positioning, and repeated after 20 minutes of stabilization, once in
prone position.
Inclusion Criteria:
- COVID-19 patients admitted in the ICU receiving invasive mechanical ventilation and
requiring prone positioning for severe hypoxemia management, as decided by the
medical team
Exclusion Criteria:
- Severe peripheral vasculopathy
- Raynaud's syndrome
- Skin lesions/trauma in upper limbs interfering the placement of the NIRS probe
and/or the occlusion tourniquet
- Deep venous thrombosis in the upper limbs
Hospital de Clñinicas da UNICAMP
Campinas, Sao Paulo, Brazil
Hospital General de México
México, Mexico
Parc Taulí Hospital Universitari
Sabadell, Barcelona, Spain
Hospital Clínic i Provincial de Barcelona
Barcelona, Spain
Hospital Parc Salut Mar
Barcelona, Spain
Hospital Vall d'Hebron
Barcelona, Spain
Jaume Mesquida, MD, PhD
+34 937231010 - 21155
jmesquida@tauli.cat
Jaume Mesquida, Principal Investigator
Parc Taulí Hospital Universitari