The consensus therapeutic strategy implies that COVID patients with acute lung injury due to coronavirus are routinely placed in prone position in an attempt to improve oxygenation by increasing ventilation homogeneity. The purpose of the study is to quantify with the electrical impedance tomography (EIT) the changes in the ventilation and aeration in the dorsal regions of the lung when the patient is placed in prone position.
Patients with acute respiratory distress syndrome (ARDS) frequently develop atelectasis in
dorsal lung regions because of gravity and the compression by the heart and the diaphragm.
Since lung perfusion is predominantly distributed in lower lung regions, a reduction of
ventilation in these areas results in further ventilation-perfusion mismatch, called shunt.
The development of atelectatic lung regions necessitate the use of higher ventilation
pressures, which in turn results in excessive transpulmonary pressures and
ventilation-induced lung injury in the ventral regions. Therefore it is common to promote the
prone position in patients with ARDS in order to improve ventilation-perfusion matching and
thus, protect the ventral regions from hyperinflation. In patients with COVID-19-related
ARDS, the value of such therapeutic strategy based on placing in prone position has not been
completely elucidated. The aims of the study are to determine whether prone positioning
improves dorsal regional ventilation when compared to supine position. Moreover, another aim
is to assess the changes in intrapulmonary shunt following patient position changes.
Other: Prone positioning
Change the positioning of the COVID patients who are intubated and mechanically ventilated from supine to prone
Inclusion Criteria:
Patients fulfilling all the following criteria are eligible for the study:
- Mechanically ventilated
- Fit the Berlin Definition for moderate or severe acute respiratory distress syndrome
(arterial oxygen partial pressure over inspiratory fraction of oxygen less than 200
mmHg)
- Infection with coronavirus confirmed
- Scheduled to undergo prone positioning
Exclusion Criteria:
- Patients with pacemakers, defibrillators or other electrically active implants
- Patients with damaged skin or impaired skin contact of the electrodes due to wound
dressings
- Patients with chest tubes
- History of thoracic surgery or lung resection
University Hospitals of Geneva
Geneva, Switzerland
Walid Habre, MD, PhD, Principal Investigator
University of Geneva