The aim of the study is to assess the safety, efficacy, and immunogenicity of AZD1222 for the prevention of COVID-19.
The COVID-19 pandemic has caused major disruption to healthcare systems with significant
socioeconomic impacts. Currently, there are no specific treatments available against COVID-19
and accelerated vaccine development is urgently needed. A safe and effective vaccine for
COVID-19 prevention would have significant public health impact.
Biological: AZD1222
AZD1222 is a recombinant replication-defective chimpanzee adenovirus expressing the SARS-CoV-2-5 surface glycoprotein.
Biological: Placebo
Commercially available 0.9% (n/V) saline for injection.
Inclusion Criteria:
- Increased risk of SARS-CoV-2 infection
- Medically stable
Exclusion Criteria:
- confirmed or suspected immunosuppressive or immunodeficient state
- significant disease, disorder, or finding
- Prior or concomitant vaccine therapy for COVID-19
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Phoenix, Arizona, United States
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Scottsdale, Arizona, United States
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Little Rock, Arkansas, United States
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Berkeley, California, United States
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El Centro, California, United States
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Los Angeles, California, United States
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Los Angeles, California, United States
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San Diego, California, United States
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San Diego, California, United States
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San Francisco, California, United States
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San Francisco, California, United States
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Torrance, California, United States
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Denver, Colorado, United States
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Danbury, Connecticut, United States
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Coral Gables, Florida, United States
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Lake Worth, Florida, United States
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Miami Lakes, Florida, United States
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Orlando, Florida, United States
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Honolulu, Hawaii, United States
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Meridian, Idaho, United States
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Chicago, Illinois, United States
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Indianapolis, Indiana, United States
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Ankeny, Iowa, United States
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Fairway, Kansas, United States
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Kansas City, Kansas, United States
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Wichita, Kansas, United States
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Wichita, Kansas, United States
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Lexington, Kentucky, United States
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Lake Charles, Louisiana, United States
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Monroe, Louisiana, United States
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Baltimore, Maryland, United States
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Baltimore, Maryland, United States
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Bethesda, Maryland, United States
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Boston, Massachusetts, United States
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Boston, Massachusetts, United States
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Ann Arbor, Michigan, United States
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Royal Oak, Michigan, United States
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Minneapolis, Minnesota, United States
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Gulfport, Mississippi, United States
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Butte, Montana, United States
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Portsmouth, New Hampshire, United States
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Berlin, New Jersey, United States
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Albuquerque, New Mexico, United States
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Bronx, New York, United States
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Brooklyn, New York, United States
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Mineola, New York, United States
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New York, New York, United States
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New York, New York, United States
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New York, New York, United States
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Rochester, New York, United States
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Rochester, New York, United States
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Valhalla, New York, United States
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Durham, North Carolina, United States
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Cincinnati, Ohio, United States
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Columbus, Ohio, United States
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Yukon, Oklahoma, United States
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Portland, Oregon, United States
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Pittsburgh, Pennsylvania, United States
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Warwick, Rhode Island, United States
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Charleston, South Carolina, United States
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North Charleston, South Carolina, United States
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Spartanburg, South Carolina, United States
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Knoxville, Tennessee, United States
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Nashville, Tennessee, United States
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Austin, Texas, United States
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Dallas, Texas, United States
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Fort Sam Houston, Texas, United States
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Houston, Texas, United States
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McAllen, Texas, United States
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San Antonio, Texas, United States
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Spring, Texas, United States
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West Jordan, Utah, United States
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Burlington, Vermont, United States
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Fort Belvoir, Virginia, United States
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Richmond, Virginia, United States
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Seattle, Washington, United States
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South Charleston, West Virginia, United States
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Madison, Wisconsin, United States
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Quillota, Chile
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Santiago, Chile
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Santiago, Chile
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Callao, Peru
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Cercado De Lima, Peru
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Lima, Peru