COVID-19 originated from Severe Acut Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) infection leads to critical condition due to hypoxemic respiratory failure with the background of viral pneumonia. Both alevolar recruitment and the subsequent optimal positive end-expiratory pressure (PEEP) adjustment has a pivotal role in the elimination of atelectasis developed by inflammation in the lung parenchyma The gold standard of the follow up of recruitment manoeuvre is the chest computed tomography (CT) examination. However, reduction of intrahospital transport and the exposure with healthcare workers are recommended because of the extremely virulent pathogen spreading easily by droplet infection. In this case bedside investigations have an utmost importance in the management of hygiene regulations. Electric impedance tomography (EIT) is a non-invasive, radiation free functional imaging technique easily applicable at the bedside.
COVID-19 originated from Severe Acut Respiratory Syndrome Coronavirus-2 (SARS-CoV-2)
infection leads to critical condition in 5% of the cases due to hypoxemic respiratory failure
with the background of viral pneumonia. 90% of these patients require invasive mechanical
ventilation on critical care units. Both alevolar recruitment and the subsequent optimal
positive end-expiratory pressure (PEEP) adjustment has a pivotal role in the eliminitaion of
atelectasis developed by inflammation in the lung parenchyma.
The gold standard of the follow up of recruitment manoeuvre is the chest computed tomography
(CT) examination. However, reduction of intrahospital transport and the exposure with
healthcare workers are recommended because of the extremely virulent pathogen spreading
easily by droplet infection. In this case bedside investigations have an utmost importance in
the management of hygiene regulations.
Electric impedance tomography (EIT) is a non-invasive, radiation free functional imaging
technique easily applicable at the bedside. With the help of EIT, intrathoracic impedance
changes, resulting from air and blood volume variations, can be determined by
circumferentially attached surface electrodes around the thorax, applying small alternating
currents and measuring differences in surface potentials. The calculated difference in
potential is utilised to reconstruct impedance images what is employed to assess ventilation
and perfusion distribution. Several local and global variances can be estimated just like the
ratio fo atelectatic/overdistended alveoli, the ratio of aeration in the anterior/posterior
regions, the inhomogeneity of aeration or regional compliance.
Procedure: alveolar recruitment
incremental and decremental positive end-expiratory pressure alveolar recruitment
Inclusion Criteria:
- SARS-CoV-2 positivity confirmed by polymerase chain reaction
- orotracheally intubated patients
- pressure control ventilation mode
- sedation level of minimum -4 on the Richmond Agitation Sedation Scale (RASS)
Exclusion Criteria:
- age under 18
- pregnancy
- pulmonectomy, lung resection in the past medical history
- clinically end stage chronic obstructive pulmonary disease
- sever hemodynamic instability (vasopressor refractory shock)
- sever bullous emphysema and/or spontaneous pneumothorax in the past medical history
chest drainage in situ due to pneumothorax and/or bronchopleural fistula
University of Szeged
Szeged, Hungary
András Lovas, MD PhD, Principal Investigator
SZTE AITI