Official Title
Norwegian SARS-CoV-2 Study - Virological, Clinical and Immunological Characterisation of Inpatients During the COVID-19 Outbreak: A Prospective Cohort Study
Brief Summary

Oslo University Hospital has initiated an observational study on hospitalised patients with confirmed COVID-19, the infection caused by Severe Acute Respiratory Syndrome Coronavirus type 2 (SARS-CoV-2).

Detailed Description

Infectious disease is the single biggest cause of death worldwide. New infectious agents,
such as the SARS-CoV-2, require investigation to understand pathogen biology and pathogenesis
in the host. In order to develop a mechanistic understanding of disease processes, such that
risk factors for severe illness can be identified and treatments can be developed, it is
necessary to understand pathogen characteristics associated with virulence, the replication
dynamics and in-host evolution of the pathogen, the dynamics of the host response, the
pharmacology of antimicrobial or host directed therapies, the transmission dynamics, and
factors underlying individual susceptibility.

At Oslo University Hospital, an observational study on the newly discovered emerging SARS-
CoV-2, the coronavirus that causes COVID-19 infection has started. The study has been
approved by the Regional Ethics Committee, so that inclusion of confirmed COVID-19 cases
admitted at the hospital can start immediately including the first patients needing
hospitalisation. The plan is to include more hospitals in other parts of Norway, starting
with inclusion of Akershus University Hospital, Vestre Viken Drammen Hospital and Østfold
Hospital. The study is anticipated to provide much needed data on the course of the COVID-19
infection, as well as generating knowledge about the virus and its transmission.

Recruiting
SARS Virus
Severe Acute Respiratory Syndrome

Diagnostic Test: SARS-CoV-2 PCR

SARS-CoV-2 E gene

Eligibility Criteria

Inclusion Criteria:

- Confirmed COVID-19 by screening of SARS-CoV-2 E-gene

Exclusion Criteria:

- Refusal of consent by patient or closest relative

Eligibility Gender
All
Eligibility Age
Minimum: 18 Years ~ Maximum: N/A
Countries
Norway
Locations

Vestre Viken Drammen Hospital
Drammen, Viken, Norway

Haukeland University Hospital
Bergen, Norway

Østfold Hospital Trust
Fredrikstad, Norway

Akershus University Hospital
Lørenskog, Norway

Oslo University Hospital
Oslo, Norway

University Hospital North Norway
Tromsø, Norway

St Olavs Hospital
Trondheim, Norway

Contacts

Jan C Holter, PhD
+4791195761 - +4723071155
jacaho@ous-hf.no

Susanne G Dudman, PhD
+4723071155 - +4723071155
Susanne.Dudman@ous-hf.no

Oslo University Hospital
NCT Number
MeSH Terms
Severe Acute Respiratory Syndrome