Nigelle 5 in Prevention of Influanza

This study will focus on the evaluation of the natural product Nigella Sativa in the
fractalized form. "Lactose Nigelle 5" from the Tunisian company Fractal Tun, in terms of
possible contribution to the prevention of influenza-like illnesses, in particular COVID-19

It will be carried out by more than 30 liberal Tunisian doctors, who will submit according to
the inclusion / exclusion criteria of people who will receive (free of charge) a capsule of
the Nig5 product sublingually, each day. Against a control group which will be followed with
the same protocol as the first but which will not receive the product. Randomization (even
days: nigella group, odd days: control group)

The monitoring and evaluation will last for 3 weeks with taking the product Nig5, followed by
a week without taking the product. That is 4 weeks in all.

More than 30 physicians volunteered to participate in this study without remuneration and
without consultation fees for the candidates.

This study will be supervised by Professor Riadh Boukef, head of emergency services at
Sahloul University Hospital, who will collect all the data afterwards in order to submit them
to the statistical tools in force.

Professor Boukef will be responsible for preparing the abstract and publishing it on his
behalf in the scientific journals of his choice, naming the doctors who participated as well
as the product in question and the company that markets it in Tunisia.

27 free practice doctors participate in patient recruitment: AMICHE Sondèss BAHA Mohamed BEN
AMARA Mohamed Khalil BEN ARBIA Karima BEN AYAD Afef BEN AYED KTARI Fouzia BENTALEB Mourad
BESBES Mohamed CHTOUROU Iteb DHOUIB Manel DJAIT Mohamed DJEMAL Najla ELFIDHA Mongi FOURATI
Imen FRIH Sabria FRIKHA Fahmi GHARBI Nadia KAMMOUN Naziha KETATA Mourad MHIRI Ikram NJAH
Jamil OUARGHI Sameh REGAIEG Mourad SAKKA Samar TRABELSI Hinda ZOUARI Imen ZOUARI Nassira