This is a Phase 2, multicentre, randomized, double blind, 2 arm placebo-controlled study in adults with moderate COVID-19 with gastrointestinal signs and symptoms.
Drug: Niclosamide Oral Tablet
Continued SOC therapy together with niclosamide TID for 14 days
Drug: Placebo
Continued SOC therapy together with placebo tablets matching niclosamide for 14 days
Inclusion Criteria:
- Patients hospitalized for treatment of COVID-19 with or without pneumonia, who are
expected to remain in hospital at least seven days after the randomization and who
accept continuing to be assessed for the study procedures (home or outpatient unit) up
to 6 weeks in case of discharge.
- Patients who prior to developing COVID-19 usually have normal bowel habits defined as
at least 3 stools per week and no more than 3 stools per day.
- SARS-CoV-2 infection confirmed by RT-PCR in rectal swab (or stool test) ≤2 days before
randomization by local or central lab.
- Diarrhea defined as at least 3 watery stools in the last 24 hours prior to enrolment
Exclusion Criteria:
- At the time of randomization patients requiring ICU admission or patients with severe
respiratory insufficiency requiring mechanical ventilation or with rapid worsening of
respiratory function leading to expectation for mechanical ventilation or ICU
admission.
- Evidence of rapid clinical deterioration or existence of any life-threatening
co-morbidity or any other medical condition which, in the opinion of the investigator,
makes the patient unsuitable for inclusion.