This study is carried on in Wuchang Hospital in Wuhan, China. The investigators plan to recruit 80 patients with COVID-19 and 80 matched healthy control. Using the design of case-control study, the study aims to assess the neurocognitive functions such as executive function and attentional bias in recovered patients with COVID-19 under normal and stress conditions, and to analyze the influencing factors of neurocognitive functions, such as mental health conditions, inflammation indicators and cardiopulmonary function.
Behavioral: Trier Social Stress Test
8-min oral calculation and 5-min speech
Inclusion Criteria:
- Recovered COVID-19 patients or uninfected residents in Wuhan, with an education level
above elementary school and are able to complete cognitive tasks;
- Willing to participate in this study and sign informed consent.
Exclusion Criteria:
- Subjects with body temperature> 38°C;
- Subjects who are in menstruation and pregnancy;
- Subjects suffering from cardiopulmonary diseases before the new coronary pneumonia
epidemic (such as heart disease, pulmonary hypertension, congestive heart failure,
etc.);
- Subjects with severe disturbances in consciousness, cognitive dysfunction, mental
disorders, visual and hearing disorders, bone and joint diseases, etc.;
- Subjects with abnormal immune system and severe organ dysfunction (heart, liver,
kidney, etc.);
- Subjects who are unwilling to participate in this study and cannot complete all
surveys and cognitive function tests.
Wuhan Wuchang Hospital
Wuhan, Hubei, China
Investigator: Guofu Huang, Dr
Contact: 8618162533930
94615617@qq.com
Ping Wu, Dr.
861082802470 - 509
wuping@bjmu.edu.cn
Lin Lu, Dr., Study Director
National Institute on Drug Dependence, Peking University