Official Title
Retrospective Study of the Measurement of the Efficacy of MORPHINE in the Early Management of Dyspnea in COVID-19 Positive Patients With Moderate to Severe Impairment Without Objective of Resuscitation Management (Level of Care 3 and 4) at the Hospices Civils of Lyon
Brief Summary

Morphine is used in the treatment of dyspnea and polypnea with a proven benefit on the improvement of these symptoms, both etiologically and symptomatically. This medication is used in particular in palliative care for this type of symptom. The Sars CoV2 viral pneumonia table can lead to respiratory distress. In patients with moderate to severe impairment without goal of resuscitation (level of care 3 and 4), the introduction of morphine may sometimes be necessary to relieve respiratory symptoms. These also lead to major exhaustion which can worsen the clinical picture. However, the prescription of morphine is not systematic in front of a respiratory distress table. The investigators hypothesized that early treatment with morphine lead to a better management of dyspnea, quality of live and survival in COVID-19 positive participants patients when there is not resuscitation objective management (level of care 3 and 4). The objective is to measure the efficacy of morphine in the early management of dyspnea, quality of life and survival in COVID-19 positive participants patients treated in the Hospices Civils of Lyon during COVID-19 pandemic.

Unknown status
Patients Hospitalized in the Hospices Civils of Lyon
COVID-19 Disease
Moderate to Severe Dyspnea
Without Resuscitation Objective Management

Other: No intervention / Compare the difference in respiratory rate between H0 and H12 of the initiation of morphine between the control and interventional groups

Respiratory rate is analyzed with the scope (approved by the French national medical authorities)

Eligibility Criteria

Inclusion Criteria:

- Age over 18 years.

- Having had a Covid-19 respiratory disease confirmed by PCR or TDM or anamnestic
criterion for patients living in communities for the elderly (respiratory
symptomatology suggestive and at least 3 cases confirmed in the living environment).

- Having had respiratory severity criteria: respiratory distress syndrome including FR>
25 / min and oxygen-demand> 4 L / min to maintain a SpO2> 90% at inclusion.

- Having had a defined level of care after collegial discussion notified in the file
rejecting the external cardiac massage and admission to the intensive care unit (Level
3 and 4 on the protocols of the Hospices Civils de Lyon).

- Collection of non-opposition

Exclusion Criteria:

-

Eligibility Gender
All
Eligibility Age
Minimum: 18 Years ~ Maximum: N/A
Countries
France
Locations

Hôpital de la Croix Rousse / GHN
Lyon, France

Hôpital Edouard Herriot
Lyon, France

Hôpital Lyon Sud
Pierre-Bénite, France

Contacts

Myriam Legenne
4 72 07 25 79 - +33
myriam.legenne@chu-lyon.fr

Hospices Civils de Lyon
NCT Number
Keywords
Covid-19 disease
level of care 3 and 4
morphinic treatment
dyspnea
MeSH Terms
COVID-19
Dyspnea
Morphine