Lung Structure-Function In SurVivors of Mild and SEvere COVID-19 Infection: 129Xe MRI

What is COVID-19? The ongoing Coronavirus Disease 2019 (COVID-19) pandemic is caused when an
individual is infected with the SARS-CoV-2 virus. This infection can result in pneumonia
involving the small airways and alveoli (the tiny air sacs at the end of the airways that
help oxygen get into the blood). COVID-19 can cause damage to the lungs, making it hard to
breathe without medical help. To understand what is happening to a patient's lungs, doctors
may use imaging tests such as chest x-rays or CT Scans (computed tomography). However, these
types of tests may not tell the Investigators the whole story.

What is the purpose of the study? Led by The Hospital for Sick Children (SickKids), this
study is being done to determine if MRI (magnetic resonance imaging) scans can tell the
Investigators more about the lungs of people who had COVID-19. The Investigators will use a
special type of MRI where participants breathe in a special gas (hyperpolarized xenon-129)
before they have the MRI. This gas will help the Investigators to see' the lungs. The
advantage of MRI scans is that there is no radiation involved in these types of images.

What is involved? In this study, participants will have an MRI of their lungs. The
Investigators will examine these MRI scans to see if the Investigators can identify any
changes in the structure or the function of the lung. If the Investigators do find any
changes, they will see how these changes relate to other tests that have been conducted or
other parts of the clinical story.

The participants will be asked to come to SickKids for 3 study visits. A fourth visit will be
conducted via telephone. These visits will span over 3 years. Each study visit will take
about 4 hours. If the participant is unable to attend one of the in-person visits, they will
be given the option for a phone/virtual visit instead.