Official Title
Low Dose Radiotherapy as Antinflammatory Treatment for COVID-19 Pneumonitis
Brief Summary

SARS-CoV-2 is causing an unprecedented stress on healthcare systems around the world, due to its high rate of infection and the high morbidity and mortality. The COVID-19 infection triggers an inflammatory cascade with cytokine synthesis, prompting the immune response. Low dose radiotherapy (LD-RT) (≤ 100 cGy) induces an anti-inflammatory response, lowering levels of pro-inflammatory cytokines such as IL-1β or inhibit leukocyte recruitment. LD-RT has been used historically for the pneumonia treatment reporting a rapid clinical improvement (within the first week), as well as a reduced mortality (from around 30% to 10%). Considering these results, LD-RT can potentially afford a therapeutic benefit against SARS-CoV-2. The study purpose is to evaluate prospectively the safety and efficacy of LD-RT for SARS-CoV-2.

Recruiting
COVID19

Radiation: Radiotherapy
Low-dose radiotherapy
Radiotherapy

Eligibility Criteria

Inclusion Criteria:

1. Age ≥ 60 years.

2. COVID19 + confirmed by PCR.

3. Thoracic imaging study (chest X-ray, chest CT or PET-CT), compatible with lung involvement.

4. Phase II or lung phase without any improvement with pharmacological treatment.

5. Phase III or hyper-inflammatory phase without any improvement with pharmacological treatment

6. Poor clinical and functional respiratory evolution: > 30 breaths / minute, SpO2 1000 ng / mL, PCR> 10 mg / dL or double than before.

Exclusion Criteria:

1. Severe comorbidities that could hamper the radiation treatment.

Eligibility Gender
All
Eligibility Age
Minimum: 60 Years
Countries
Spain
Contacts

Manuel Gonzalo Vazquez Masedo, MD,PhD
913003000
manuelgonzalo.vazquez@salud.madrid.org

Hospital San Carlos, Madrid
NCT Number
Keywords
RADIOTHERAPY
Antiinflammatory
PNEUMONITIS
MeSH Terms
Pneumonia