Official Title
Low Dose Radiation Therapy for Severe-Acute-Respiratory-Syndrome-Coronavirus-2 (SARS-CoV-2)
Brief Summary

This study is to analyse the efficacy of LD-RT for treatment of Severe-Acute-Respiratory-Syndrome-Coronavirus-2 (SARS-CoV-2).

Detailed Description

Management of patients with SARS-CoV-2 presents a great challenge in the ongoing pandemic.
The inflammatory reaction, evident in the later stages of the disease, is linked with high
mortality rates. Pharmaceutical interventions at this stage often do not achieve the desired
effects. Low Dose Radiation Therapy (LD-RT) has been utilized for treatment of inflammatory
conditions because of its immunomodulatory effects. Thus, LD-RT may be an option in
SARS-CoV-2 based on pre-clinical models and early clinical data. This study is to analyse the
efficacy of LD-RT for treatment of Severe-Acute-Respiratory-Syndrome-Coronavirus-2
(SARS-CoV-2).

Status
Completed
Conditions
Severe-Acute-Respiratory-Syndrome-Coronavirus-2 (SARS-CoV-2)
Interventions

Radiation: Low Dose Radiation Therapy (LD-RT)

Low Dose Radiation Therapy (LD-RT) of both lungs with 1 Gray

Other: Sham irradiation

Sham irradiation

Eligibility Criteria

Inclusion Criteria:

- Age of male patients >40 years

- Age of female patients >50 years

- Patients with SARS-CoV-2 requiring mechanical ventilation

- Informed consent obtained by the legal representative of the patient

Exclusion Criteria:

- Pregnancy

Eligibility Gender
All
Eligibility Age
Minimum: 40 Years ~ Maximum: N/A
Countries
Switzerland
Locations

Department of Radiooncology, University Hospital Basel
Basel, Switzerland

Investigators

Alexandros Papachristofilou, Dr. med., Principal Investigator
Department of Radiooncology, University Hospital Basel

Sponsors / Collaborators
University Hospital, Basel, Switzerland
NCT Number
NCT04598581
Keywords
Low dose radiation therapy (LD-RT)
MeSH Terms
Coronavirus Infections
Severe Acute Respiratory Syndrome
Syndrome