Multicenter retrospective and prospective observational study based on the collection of sequential anonymized data from principal Italian ITP centers, to describe the clinical course of ITP patients becoming infected by SARS-CoV-2 and of COVID-19 patients developing de novo ITP.
Multicenter retrospective and prospective observational study based on the collection -
through pre-piloted electronic CRFs - of sequential anonymized data from principal Italian
ITP centers representative of national geographical distribution, to evaluate, during a
2-years study period, both the cumulative incidence COVID-19 occurring in patients with prior
or ongoing ITP (COVID-19 in ITP) and the cumulative incidence of de novo ITP manifesting
during COVID-19 (ITP in COVID-19). Data will be collected to describe the clinical course of
patients in the two groups. The enrolment period will last 24 months or terminate at the last
day of 1-month-COVID-19 free in Italy, whichever comes first. Each patient will be followed
up to the first visit scheduled as per common center practice, including at least six months
after hospital discharge or end of quarantine home confinement.
Inclusion Criteria:
- Age ≥ 18 years
- Confirmed diagnosed of ITP (ITP could be past, ongoing, persistent >3 months, chronic
>12 months) in patients that are in regular follow-up (at least once a year) and who
have been diagnosed with COVID-19
- All patients who develop de novo ITP from 1st January 2020 to the end of study after a
diagnosis of COVID-19 or during the first 6 months after COVID-19 recovery
- Signed informed consent
Exclusion Criteria:
• All subjects not fitting inclusion criteria
ASST Degli Spedali Civili Di Brescia - UO Ematologia
Brescia, Italy
Unità di Onco-Ematologia - Azienda Ospedaliera Garibaldi
Catania, Italy
A.O.U. Careggi - Ematologia
Firenze, Italy
AOU San Luigi Gonzaga - SCDU Ematologia Generale E Oncoematologia
Orbassano, Italy
Policlinico Universitario Agostino Gemelli
Roma, Italy
Ematologia Città della Salute e della Scienza di Torino - Molinette
Torino, Italy
ASST Dei Sette Laghi - UOC Ematologia
Varese, Italy
AOU Integrata Di Verona, Policlinico G.B. Rossi - UOC Ematologia
Verona, Italy
Paola Fazi
+39 06 70390528
p.fazi@gimema.it
Enrico Crea
+39 06 70390514
e.crea@gimema.it