Official Title
Adjunctive Inspiratory Muscle Training for Patients With COVID-19
Brief Summary

This study aims to investigate whether adjunctive inspiratory muscle training (IMT) can enhance the benefits of pulmonary rehabilitation (PR) in patients with COVID-19. 120 patients will be randomized into an interventional group (PR plus IMT) and a control group (sham IMT plus PR). Improvement in quality of life, peak VO2 and VE/VCO2 slope will be defined as a primary outcome. Maximal inspiratory pressure, inspiratory muscle endurance, pulmonary function testing, severity of fatigue, cost-effectiveness and six minute walk test will be defined as the secondary outcomes.

Completed
COVID19
Exercise

Device: inspiratory muscle traiing

The patients are encouraged to inhale against a load to increase the inspiratory muscle strength and endurance
Other Name: tapered flow resistive loading

Eligibility Criteria

Inclusion Criteria:

To be eligible, participants must be:

- over 18 years of age

- confirmed COVID-19 diagnosis

- Individuals that required hospitalization and either i) non-invasive respiratory
support (CPAP, high-flow oxygen catheter, non-breathing oxygen mask, or ii) invasive
mechanical ventilation within three months of study recruitment.

Exclusion Criteria:

- Pregnancy

- Dependence on others to perform activities of daily living during the month prior to
the current ICU admission (gait aids are acceptable)

- documented cognitive impairment

- Proven or suspected spinal cord injury, or other neuromuscular diseases that will
result in a permanent or prolonged weakness (not including ICU acquired weakness)

- Severe neurological disease

- Death is deemed inevitable as a result of the current illness and either the patient
or treating clinical or substitute decision-maker are not committed to full active
treatment.

Eligibility Gender
All
Eligibility Age
Minimum: 18 Years ~ Maximum: N/A
Countries
Brazil
Locations

Secretaria de Saúde do Distrito Federal
Brasilia, DF, Brazil

Escola Superior de Ciencias da Saude
NCT Number
Keywords
Respiratory Function Tests
inspiratory muscle training
MeSH Terms
COVID-19
Respiratory Aspiration