The study aims to evaluate the reduction in severity and progression of lung injury with inhaled ibuprofen in patients with severe acute respiratory syndrome due to SARS-CoV-2 virus.
Drug: Inhaled Hypertonic ibuprofen
Standard of care plus lipid ibuprofen 50mg tid
Inclusion Criteria:
1. Provision of written informed consent by the patient OR by the patient's Legal
Representative.
2. Confirmed or suspected SARS-CoV-2 infection;
3. Pneumonia without criteria of severity.
4. With some of the following conditions:
- Diabetes.
- Cardiovascular disease.
- Chronic kidney disease.
- Chronic obstructive pulmonary disease.
- Structural diseases of the lung
- Immunocompromise.
5. Patient who presents negative results by rtPCR for SARS CoV-2, in case of being highly
suspicious, the patient may receive it empirically until the results are obtained.
6. No unstable bronchial asthma
Exclusion Criteria:
1. The doctor considers that participation in the Program is not the best for patients or
for any condition that prevents the Program from being followed safely.
2. Patients with a history of unstable bronchial asthma
3. The patient is allergic to ibuprofen or any of the compounds in the preparation.
4. Hypersensitivity to the drug, nasal polyps syndrome, angioedema or bronchospasm
against aspirin or other NSAIDs.
5. Pregnant or lactating woman, or positive pregnancy test on a pre-dose exam.
6. Patient who is expected to be transferred to another place other than the place where
the Program starts, within 7 days of starting it.
Centro de Excelencia en Productos y Procesos Córdoba
Córdoba, Argentina
Investigator: German Ambasch, MD
Contact: 54 9 351 564-2602
german.ambasch@yahoo.com.ar
Dante M Beltramo, PhD
54 9 351 766-8050
dantemiguelbeltramo@gmail.com
Nestor H García, MD, PhD
5493513539948
garcia.nestor@conicet.gov.ar
Dante M Beltramo, PhD, Study Director
Centro de Excelencia en Productos y Procesos Córdoba