Randomized, prospective, controlled open label clinical trial aimed at investigating if the addition of inhaled corticosteroids (budesonide) reduces treatment failure (defined as a composite variable by the initiation of treatment with high flow-O2 therapy, non-invasive or invasive ventilation, systemic steroids, use of biologics (anti IL-6 or anti IL-1) and/or death) according to hospital standard of care guidance) at day 15 after initiation of therapeutic intervention.
Drug: Inhaled budesonide
adding budesonide to standard of care for pneumonia in COVID19 positive patients
Inclusion Criteria:
- COVID19 positive
- hospitalized because of pneumonia (status #3 - #4 World Health Organization (WHO)
scale)
- without contraindications to receive study treatment
- informed consent
Exclusion Criteria:
- receiving corticoids (inhaled or systemic)
- receiving anti Interleukin-1 (IL-1) or anti-IL-6 drugs
- receiving high flow oxygen therapy
- receiving mechanical ventilation
- pregnancy
- participating in another intervention trial for COVID19
Hospital de Infecciosas "Francisco Javier Muñiz"
Ciudad Autonoma de Buenos Aires, Buenos Aires, Argentina
CEMIC (Centro de Educación Médica e Investigaciones Clínicas "Norberto Quirno")
Ciudad Autonoma de Buenos Aires, Buenos Aires, Argentina
Hospital de Rehabilitación Respiratoria "María Ferrer"
Ciudad Autónoma de Buenos Aires, Buenos Aires, Argentina
Hospital Donación "Francisco Santojanni"
Ciudad Autónoma de Buenos Aires, Buenos Aires, Argentina
Clínica Monte Grande
Monte Grande, Buenos Aires, Argentina
Hospital Centro de Salud Zenón J. Santillán
San Miguel De Tucumán, Tucumán, Argentina
Hospital San Juan de Dios
La plata, Argentina
Hospital de Santiago
Santiago De Compostela, A Coruña, Spain
Hospital Universitari Germans Trias i Pujol
Badalona, Barcelona, Spain
Hospital Universitari de Bellvitge
Hospitalet de Llobregat, Barcelona, Spain
Hospital del Mar
Barcelona, Spain
Hospital Universitari Vall d'Hebron
Barcelona, Spain
Hospital Clinic of Barcelona
Barcelona, Spain
Hospital de la Santa Creu i Sant Pau
Barcelona, Spain