Official Title
The Impact of Premorbid Illnesses on the Risk of ICU Admission and Short-term Outcome
Brief Summary

The Corona virus disease 2019 (COVID-19) pandemic is currently involving all parts of the world. Several risk factors for critical illness and death from the disease have been proposed. However, it is still unclear if the observed associations between different comorbidities and chronic medications and severe COVID-19 disease and mortality is different from associations between the same factors and other severe diseases requiring intensive care unit (ICU) -care. This is important since some of the observed risk factors are very common in the aged who, by age alone, are more prone to a more severe course of any disease. By combining several registries, this study will compare, on several comorbidities such as hypertension and diabetes , the first 2000 cases of COVID-19 patients receiving critical care in Sweden to a Swedish sepsis-cohort and a Swedish adult respiratory distress syndrome (ARDS) -cohort.

Detailed Description

The Corona virus disease 2019 (COVID-19) pandemic is currently involving all parts of the
world. Several risk factors for critical illness and death from the disease have been
proposed. However, it is still unclear if the observed associations between different
comorbidities and chronic medications and severe COVID-19 disease and mortality is different
from associations between the same factors and other severe diseases requiring ICU-care. This
is important since some of the observed risk factors are very common in the aged who, by age
alone, are more prone to a more severe course of any disease. By combining several
registries, this study will compare, on several comorbidities such as hypertension and
diabetes , the first 2000 cases of COVID-19 patients receiving critical care in Sweden to a
Swedish sepsis-cohort and a Swedish ARDS-cohort.

Completed
Sepsis
Corona Virus Infection
ARDS, Human

Other: No intervention, observational study

Eligibility Criteria

Inclusion Criteria:

° Individual registered in the Swedish intensive care registry (SIR) with COVID-19 Before
27 May 2020.

or

- Individual registered in the SIR with Severe sepsis or septic chock 2011-2016. or

- Individual registered in the SIR with ARDS 2011-2016.

Exclusion Criteria:

- Age below 18 years

- Individual registered in the Swedish intensive care registry without a personal
identification number

Eligibility Gender
All
Eligibility Age
Minimum: 18 Years ~ Maximum: N/A
Countries
Sweden
Locations

Björn Ahlström
Falun, Sweden

Miklos Lipcsey, PhD, Principal Investigator
Uppsala University

Center for Clinical Research Dalarna, Sweden
NCT Number
MeSH Terms
Coronavirus Infections
Respiratory Distress Syndrome