Breath analysis is the evaluation of exhaled air of humans. It aims to get information about the clinical status of a human being by monitoring its volatile organic compounds (VOCs) in exhaled air. In this feasibility study it is intended to find specific biomarker(s) in exhaled breath indicating an infection with SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2).
Device: Ion Mobility Spectrometry (IMS)
Two breathing gas samples will be taken from each study participant using ion mobility spectrometry with an ultrasound-based spirometer. The total sampling time is 1 minute (at least 5-7 breath takes) following an analysis time of 5-12 minutes.
Inclusion Criteria:
- SARS-CoV-2-Polymerase chain reaction (PCR) test result is available
- Signs or symptoms of any respiratory system infection or Signs or symptoms indicating
SARS-CoV-2 infection or Radiological findings suggesting viral lung infection
- Breath test (Study intervention) must be performed within a 2 day time period after
latest SARS-CoV-2 PCR
Exclusion Criteria:
- History of SARS-CoV-2 outside the current respiratory episode (known from medical
history)
- Participation in another clinical study prior to breath analysis which could influence
the result of the breath analysis
Charité - Universitätsmedizin Berlin, Campus Benjamin Franklin
Berlin, Germany
Technical University of Munich, Klinikum rechts der Isar
Munich, Germany
Christoph Spinner, PD Dr., Principal Investigator
Technical University of Munich, Klinikum rechts der Isar