Official Title
Hydroxychloroquine to Prevent COVID-19 Disease Amongst Healthcare Workers (PROVIDE): A Parallel Randomized Controlled Trial
Brief Summary

The objectives of PROVIDE are to: 1. Determine if prophylactic once weekly hydroxychloroquine reduces the incidence of conversion from SARS-2-CoVnasopharyngeal swab negative to positive 2. To determine if weekly prophylactic hydroxychloroquine reduced the severity of COVID-19 symptoms 3. To determine the safety of taking weekly prophylactic hydroxychloroquine

Not yet recruiting
Corona Virus Infection

Drug: Apo-Hydroxychloroquine
Hydroxychloroquine sulfate 400mg PO BID on day one, then 400mg PO weekly, to be taken with meals for two months total.
Intervention - Hydroxychloroquine

Drug: Matched Placebo
Matching Placebo

Eligibility Criteria

Inclusion Criteria:

- 18 years of age or older to participate.

- Healthcare workers with primary practice in intensive care unit, general internal medicine,

- COVID-19 testing centres, emergency rooms, and nursing homes.

- COVID_19 symptom free at the time of randomization and have a negative diagnostic swab.

Exclusion Criteria:

- Known COVID-19 positivity defined as: a laboratory confirmed case as defined by the local public health institutes

- Suspected COVID-19 positivity defined as possessing symptoms consistent with COVID-19 infections such as: headache, fever, nausea, vomiting, diarrhea, dyspnea, dry cough

- Healthcare workers with pre-existing retinopathy or serious visual problems

- Healthcare workers with known malignancies receiving active chemotherapy or immune modifying medications

- Healthcare workers with known autoimmune disorders

- Healthcare workers with known QT prolongation

- History of ventricular arrhythmias

- Participants at risk of malignant arrythmias ○ At risk defined as: A sudden loss of consciousness with injury; anyone in their immediate family, under the age of 45year, with sudden cardiac death; anyone family history of long QT syndrome - Known sensitivity/allergy to hydroxychloroquine - Healthcare workers that are currently pregnant - Healthcare workers that are already taking chloroquine or hydroxychloroquine - Healthcare workers on colchicine or any other anti-viral medication - Healthcare workers taking a medication that may interact with hydroxychloroquine (see table below - Inability to take oral medications - Inability to provide written consent - Known G6PD deficiency

Eligibility Gender
Eligibility Age
Minimum: 18 Years

Kimberley Lewis

Waleed Alhazzani

St. Joseph's Healthcare Hamilton
NCT Number
MeSH Terms
Coronavirus Infections
Severe Acute Respiratory Syndrome