This study is a interventional study that present minimal risks and constraints to evaluate the presence of novel coronavirus (SARS-CoV-2) or antibodies among individuals living in households where there is a confirmed coronavirus case in order to provide useful information on the proportion of symptomatic forms and the extent of the virus transmission in tropical regions such as French Guiana, Guadeloupe and New-Caledonia.
This study is a interventional study that present minimal risks and constraints to evaluate
the presence of novel coronavirus (SARS-CoV-2) or antibodies among individuals living in
households where there is a confirmed coronavirus case in order to provide useful information
on the proportion of symptomatic forms and the extent of the virus transmission in tropical
regions such as French Guiana, Guadeloupe and New-Caledonia.
Subjects will be assessed (questionnaires and sampling) in their homes. Subjects will be
asked to attend study visits at days 0, 7, 14, 21, 28, 60, 90, 180 and 360.
The primary objective of the study is to evaluate the rate of intra-household secondary
transmission of the virus.
Procedure: Human biological samples
Blood sample
Nasopharyngeal swab.
Inclusion Criteria:
- Primary case: laboratory-confirmed coronavirus SARS-CoV-2 infection by polymerase
chain reaction (PCR),
or Family contact in French Guiana and Guadeloupe: person who lived in the same household
as the primary case of COVID-19 when the primary case was symptomatic. A household is
defined as a group of people (2 or more) living in the same accommodation (excluding
residential institutions such as boarding schools, dormitories, hostels, prisons, other
communities hosting grouped people),
or Close contact in New-Caledonia: any individual who was in contact with a primary case,
in his/her family/living environment, work/school, friends/leisure or means of transport,
when the primary case was symptomatic or presymptomatic,
- Affiliated or beneficiary of a social security system
- Informed consent prior to initiation of any study procedures from subject (or legally
authorized representative)
- State of health compatible with a blood sample as defined in the protocol.
Exclusion Criteria:
- Inability to consent
- Person under guardianship or curatorship
- Known pathology or a health problem contraindicated with the collect of blood sample.
Centre Hospitalier Andrée Rosemon
Cayenne, French Guiana
Institut Pasteur de la Guyane
Cayenne, French Guiana
Institut Pasteur de Guadeloupe
Les Abymes, Guadeloupe
Institut Pasteur de Nouvelle-Calédonie
Nouméa, New Caledonia
Claude Flamand, PhD, Principal Investigator
Institut Pasteur de la Guyane, Head of Epidemiology Unit