Official Title
Host-pathogen Interactions, Immune Response, and Clinical Prognosis at COVID-19 - the CoVUm Trial
Brief Summary

The project aims to clarify how immunity to SARS-CoV2 develops in humans and to investigate the possibility of finding patients with a particularly effective, neutralizing antibody response for future treatment. The project also aims to detail the virus's damage mechanisms in tissue.

Detailed Description

There is currently a mounting body of evidence regarding the pathogenesis of COVID-19 caused
by SARS-CoV2. By gaining more knowledge about the mechanisms in the development of viral
pneumonia and the influence of other organ systems at SARS-CoV2, we believe that in the
future it is better to be able to identify precisely those persons who are at risk of serious
illness. To this we will gain knowledge of how humans develops immunity to the virus and also
how human epigenetic (acquired) ability to activate inflammatory genetic systems can limit
the harmful effects of the virus. Thus, patients who have had mild or no symptoms are just as
interesting from a study point of view as those who have had severe symptoms. Hopefully, such
understanding can also contribute to other opportunities for targeted treatment (by
identifying patients who can mount effective inborn and adaptive host defenses) in order to
prevent severe disease and death in pandemic corona infection.

Active, not recruiting

Procedure: Extended sampling and procedures

The study patients will give additional blood samples and also urine and faeces samples. Spirometry and additional biometric controls will be performed regularly. Necrobiopsies of various organs from deceased patients will be secured and stored for immunohistological and virological analysis.

Eligibility Criteria

Inclusion Criteria:

- Patients between 15-100 years with SARS-CoV2 or influenza

- Patients admitted for COVID-19 or Influenza-caused pneumonia/ pneumonitis at the
Departments of Infectious Diseases or ICU, Umeå University Hospital, Örebro hospital,
Karlstad hospital and Västerås hospital

- Patients with COVID-19 who are treated in outpatient care at the infectious Diseases
Clinic, Umeå University Hospital, Sweden

- Patients who give written informed consent to participate in the study for the entire
follow- up period of 5 years.

Exclusion Criteria:

- Age less than 15 years

Eligibility Gender
Eligibility Age
Minimum: 15 Years ~ Maximum: 100 Years

Incectious Diseases Clinic
Umeå, Västerbotten, Sweden

Karlstad hospital
Karlstad, Sweden

Västerås hospital
Västerås, Sweden

Örebro university hospital
Örebro, Sweden

Johan Normark
NCT Number
MeSH Terms