The outbreak of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been declared a public health emergency of international concern. Hospitalized COVID-19-positive patients requiring ICU care is increasing along with the course of epidemic. A large number of these patients developed acute respiratory distress syndrome (ARDS) according to current data. However, the related hemodynamic characteristic has so far been rarely described.
The outbreak of COVID-19 is a worldwide concern. To our knowledge, the details of the
hemodynamic characteristics of COVID-19 patients have not yet been well described. Besides,
the cardiac injury was reported in about 7-17% of hospitalized patients with COVID-19 in
previous Chinese publications and is much more common in patients admitted to ICU and
non-survivors. However, no systematic assessment, including echocardiography evaluating the
left ventricular function of these patients has been declared. In addition, extravascular
lung water (EVLW) and pulmonary capillary permeability are two hall markers in ARDS patient's
management, and transpulmonary thermodilution is a validated method to provide these values
at the bedside. However, no study has reported the characteristic profile of these variables
during ARDS caused by SARS-Cov2. A better knowledge of these characteristics would also be
helpful in guiding their management.
Device: Transpulmonary thermodilution
Obtained by averaging the results of three thermodilution measurements. Each thermodilution is performed by injecting a bolus (15 mL) of cold saline (less than 10°C)
Device: Echocardiography
Daily echocardiography evaluation
Inclusion Criteria:
- Confirmed or suspected SARS-Cov2 cases
- Patients admitted to ICU, defined as a unit in which patients can receive
vasopressors.
- Monitored by a transpulmonary thermodilution system (PiCCO2 (Pulsion Medical Systems,
Feldkirchen, Germany) or EV1000 (Edwards Lifesciences, Irvine, United States of
America).
Exclusion Criteria:
- SARS Cov-2 Negative
- Refusal to participate in the study
Bicetre Hospital
Paris, Val-de-Marne, France