All patients with heart disease should have the opportunity to participate in research into their condition, to advance knowledge and treatment. The HeartHive COVID-19 study is an international online pilot observational cohort study evaluating the impact and clinical outcomes of the COVID-19 pandemic on subjects enrolled in the HeartHive. Cardiomyopathies are progressive diseases, and there is a need to better understand what factors affect the chances of developing cardiomyopathy, and how the condition progresses. The impact of the COVID-19 pandemic on patients with cardiomyopathy has not been explored and represents a critical unmet need. Insights into exposure, healthcare outcomes, behavioural changes and the psychosocial ramifications of the pandemic are required to better understand the health needs of this population during these unprecedented circumstances and to adapt clinical services to meet these. The study will entail completing serial online surveys during the pandemic. This study uses The Heart Hive - an international, online registry of patients with self-reported clinically diagnosed cardiomyopathy, and people without heart disease. Participants enrol and upload their own data through the website. It is the second research study that will be offered to registry participants and delivered through The Heart Hive platform.
The impact of the COVID-19 pandemic on patients with cardiomyopathy has not been explored and
represents a critical unmet need. Insights into exposure, healthcare outcomes, behavioural
changes and the psychosocial ramifications of the pandemic are required to better understand
the health needs of this population during these unprecedented circumstances and to adapt
clinical services to meet these.
The requirements for the population to limit social interaction and stay at home
significantly limits conventional research approaches to studying the effect of the pandemic
on patients. The Heart Hive platform circumnavigates this by offering an online mechanism to
gain insight into the effect of the pandemic in a pre-assembled cohort of patients rapidly
and in real-time as the pandemic evolves without any risk to patients.
This study is framed around the following hypotheses:
1. Patients with cardiomyopathy who contract COVID-19 are at greater risk or death or
hospitalisation than subjects without heart disease.
2. Patients with cardiomyopathy perceive themselves to be at enhanced risk and are more
likely to be following national recommendations on social restriction measures than
subjects without heart disease.
3. Patients with cardiomyopathy have experienced interruption to the delivery of their
usual cardiology/cardiomyopathy clinical service as a result of the pandemic.
4. Patients with cardiomyopathy are less likely to seek medical help due to fear of
contracting COVID-19.
5. The psychological impact of the pandemic is greater in patients with cardiomyopathy than
in subjects without heart disease.
Primary Objectives:
1. To conduct serial surveys in patients with cardiomyopathy and subjects without heart
disease evaluating the health-related, behavioural and psychosocial impact of the
COVID-19 pandemic.
2. To use national registries, including NHS Digital, Office for National Statistics (ONS),
Hospital Episodes Statistics (HES) and medical records to longitudinally assess hospital
admissions and patient mortality from COVID-19 for UK-based participants.
Secondary Objectives:
1. To use serial surveys to evaluate the indirect impact of COVID-19 on access to healthcare
amongst patients with cardiomyopathy.
The Heart Hive COVID-19 study is an international online pilot observational cohort study
evaluating the impact and clinical outcomes of the COVID-19 pandemic on subjects enrolled in
the Heart Hive. Patients with heart muscle disease and subjects without heart disease who are
Heart Hive registry members are eligible to enrol. Eligible subjects who provide informed
consent will be enrolled. The study will entail completing serial online surveys during the
pandemic. For subjects who live in the UK who provide consent, health information and outcome
data will also be collected from NHS digital, national registries (e.g. ONS, HES, DID) and
medical records.
Other: COVID-19 experience surveys
Serial online surveys recording experiences of the COVID-19 pandemic.
Inclusion Criteria:
- Adult (age 18 and over) Males or Females
- Capacity to provide informed consent
- Subjects with either:
- A self-reported confirmed diagnosis of cardiomyopathy (dilated cardiomyopathy,
hypertrophic cardiomyopathy, arrhythmogenic cardiomyopathy, restrictive
cardiomyopathy, left ventricular non-compaction cardiomyopathy) Or
- No self-reported history of heart disease
Note: Pregnant women are eligible. This study is observational and entirely separate from
clinical care.
Exclusion Criteria:
- Patients who lack capacity to consent for themselves Vulnerable groups (e.g. those under
18, prisoners, those in a dependent relationship, the mentally ill)
- Although usually considered a vulnerable group, pregnant women are eligible for this
study which is observational and entirely separate from clinical care.
Patients with a confirmed history of coronary artery disease:
- who have been informed by their treating physician that their cardiomyopathy is
secondary to their coronary artery disease, or
- who have undergone previous percutaneous coronary intervention or coronary bypass
surgery History of primary valvular heart disease or congenital heart disease Severe,
untreated or untreatable hypertension (systolic blood pressures routinely >180 mm Hg
and/or diastolic blood pressures >120 mm Hg)
Imperial College London
London, United Kingdom
James S Ware, Principal Investigator
Imperial College London