A rapid oxygen desaturation has observed in patients with COVID-19 which have seriously respiratory failure and most of them have intubated and connected to the mechanical ventilator. Finally, many of them have died during the process. ORF8 and superficial glycoproteins of a novel coronavirus bind to porphyrin on haemoglobin molecules and inhibit heme metabolism in an erythrocyte. However, it is not clarify the effects of the novel coronavirus on mean corpuscular volume (MCV), mean corpuscular of haemoglobin (MCH) and mean corpuscular haemoglobin concentration (MCHC).
In late December 2019, cases of pneumonia of unknown etiology began to appear in Wuhan,
Hubei, China. This disease, which was named COVID-19 by the World Health Organization (WHO)
on February 11, 2020, was identified as serious acute respiratory syndrome coronavirus-2
(SARS-CoV-2). The disease, which spread rapidly from person to person, quickly became a
pandemic in the world.
Some of the patients who admitted with high fever, cough and respiratory distress have been
curing in intensive care units due to severe respiratory failure. A rapid oxygen desaturation
has observed in these patients, and most of the patients have intubated and connected to the
mechanical ventilator, but many of them have died in this process. Until May 02, 2020,
approximately 3,5 million COVID-19 cases were detected throughout the world and nearly 250
thousand people died.
In this process, to identfy the reasons of the respiratory failure and oxygen desaturation
has a high scientific value. Alveolar edema and reactive pneumocyte hyperplasia accompanied
by inflammatory infiltration in the lung during the early stage of infection may cause
disruption of oxygen transport. In some cases, the alveolar exudate organization and
pulmonary interstitial fibrosis accompany this process, and the desquamation of the mucosal
epithelium and the bronchi are covered with a mucous plug. The resulting destruction is
thought to cause desaturation by affecting oxygen transport.
A novel coronavirus has a positive stranded RNA nucleic acid. In addition to its structural
spikes, envelope and membrane proteins, it has non-structural proteins such as ORF1ab, ORF3a,
ORF6, ORF7a, ORF10 and ORF8. Inhibitory effects of these proteins on haemoglobin may be a
reason for rapid desaturation. By binding to the porphyrin of ORF8 and superficial
glycoproteins on the hemoglobin, it inhibits the "heme" metabolism and patients' haemoglobin
levels may be low. However, it is not clear the effects of the disease on mean corpuscular
volume (MCV), mean corpuscular of haemoglobin (MCH) and mean corpuscular haemoglobin
concentration (MCHC). Demonstrating the relationship between these parameters and the
severity of the disease is of great importance in the treatment of the disease in terms of
further studies.
The aim of this study is to reveal the effects of the disease on erythrocyte indices and to
show the effectiveness of erythrocyte indices in predicting the severity of the disease.
Other: File scanning
RBC, HGB, HCT, MCH, MCV, MCHC, WBC values will be noted in the hemogram test performed at the time of initial admission
Inclusion Criteria:
- All patients with COVID-19 test (+) using the PCR technique
Exclusion Criteria:
- Those receiving blood products or any drugs that will affect their blood values before
admission
- Those patient with any hematologic diseases
Konya Training and Research Hospital
Konya, Turkey
Investigator: Yasin Tire
Contact: 0903322020
makifyazar51@gmail.com